1156491-10-9,(1R trans)-2-(3,4-difluorophenyl)cyclopropane Amine For Tecagrelor

Incoterm: FOB
Min. Order: 1 Kilogram
Delivery Time: 1 Days

Basic Info

Model No.: 1156491-10-9

Additional Info

Packaging: AS REQUIRED

Productivity: KGS


Transportation: Air

Place of Origin: CHINA


Certificate: ISO

Product Description

Our company supply a great deal of (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochlorideCAS No. 1156491-10-9 with high quality and attractive price which has the molecular formula of C9H9F2N.HCl and Molecular Weight of 205.63. (1R trans)-2-(3,4-difluorophenyl) cyclopropane amine 1156491-10-9 is an intermediate of Ticagrelor, which is used as a reversible antagonist of the platelet purinergic P2Y12 receptor. 

Ticagrelor intermediate (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride cas number is 1156491-10-9,His synthesis process is as below:
150 ml of cyclohexane, 0.75 g of 2-(3,4-difluorophenyl)cyclopropylamine, 0.75 mg of CALB, 0.75 mg of 5% Pd/C, and 0.39 g of acetic acid B were added to a 250 ml Erlenmeyer flask. The ester was placed in a shaker, the temperature of the shaker was set to 30 ° C, 250 rpm, and the reaction was carried out for 8 hours. The conical flask was taken out, cooled to 25 ° C, Pd/C and CALB were recovered by filtration, and the solvent was recovered by rotary evaporation. ML, 16.2 g of 1% aqueous hydrochloric acid solution was added dropwise to the residual oil, stirred at 30 ° C for 8 hours, 1% NaOH was added dropwise to the solution, the pH of the control system was 8-9, and the above-mentioned recovered cyclohexane was added. 145 ml of the extract was separated, and the organic phase was evaporated to yield cyclohexane to give 0.56 g of (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride cas number  1156491-10-9

Thera. Category:  P2Y12 receptor

Cas No.: 1156491-10-9

Synonyms:(1R,2S)-2-(3,4-difluorophenyl)cyclopropanaMine Hydrochloride(1:1);(1R,2S)-2-(3,4-Difluorophenyl)-cyclopropan-1-aMine HCL;(1R trans)-2-(3,4-difluorophenyl)cyclopropane aMine hydrochloride; (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine;(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride;CYCLOPROPANAMINE, 2-(3,4-DIFLUOROPHENYL)-, HYDROCHLORIDE (1:1), (1R,2S)-REL-;(1S,2R)-2-(3,4-difluorophenyl)cyclopropanaMine;trans-(1R,2S)-2-(3,4-difluorphenyl)cyclopropylaMine;

Molecular FormulaC9H9F2N.HC

Molecular Weight205.63


Assay: ≥99%

PackingExport worthy packing

Material Safety Data SheetAvailable on request

Related intermediate:

1) 274693-27-5 Ticagrelor

2) 4,6-Dichloro-5-nitro-2-(propylthio)pyrimidine 145783-14-8

3) 4,6-Dichloro-2-propylthiopyrimidine-5-amine 145783-15-9

4)  (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine L-Tartaric acid  220352-39-6

5) 1156491-10-9, (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine

6) 376608-74-1, Ethanol,2-[[(3aR,4S,6R,6aS)-6-[[5-aMino-6-chloro-2-(propylthio)-4-pyriMidinyl]aMino]tetrahydro-2,2-diMethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-

7) 376608-71-8, (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R)-Hydroxy(phenyl)ethanoate

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