2-Methyl-5-AMiobenzenesulfonmide For Pazopanib CAS 6973-09-7

Unit Price: USD 1.0000 / Kilogram
Incoterm: FOB
Min. Order: 1 Kilogram
Delivery Time: 7 Days

Basic Info

Model No.: 6973-09-7

Additional Info

Packaging: 1KGS/DRUM

Productivity: Commercial scale


Place of Origin: CHINA

Product Description

2-Methyl-5-AMiobenzenesulfonmide is Pazopanib intermediate CAS number is 6973-09-7, the appearance of a white solid. Its production process is relatively simple, with p-nitrotoluene as raw material, after vigorous stirring by adding chlorosulfonic acid, through the continuous feeding method to get the first step reaction product of 5 - nitro - 2 - methyl benzene sulfonyl chloride, the product without going through Purification,directly used for the next step. Then add 4-nitro-2-methylbenzenesulfonyl chloride, iron powder, ammonium chloride and ethanol to the reaction kettle by turn, and the temperature was raised to reflux for 3 hours. The equipment was dried by hot suction, evaporated to dryness, Crystallization,get the desired product, 2-Methyl-5-AMiobenzenesulfonmide CAS number 6973-09-7, This step intermediate and pazopanib intermediate 7 through condensation and forming salt to prepare pazopanib hydrochloride. In this step, we believe that the use of isopropyl alcohol in the literature as a reaction solvent is not appropriate and should be replaced with ethanol, which can reduce the cost and toxicity, and the ether used for washing the filter cake should also be replaced by ethanol, which is more suitable for industrial production.

Thera. Category: Anti -cancer

Cas No.: 6973-09-7

Synonym:3-Amino-6-methylbenzenesulfonamide 5-Amino-2-methylbenzenesulfonamide;6973/9/7;2-METHYL-5-AMINOBENZENE SULFONAMIDE;3-Amino-6-methylbenzenesulfonamide;methyl 2,4-difluoro-5-nitrobenzoate;Nsc36969;5-aMino-2-Methylbenzene-1-sulfonaMide;2-Methyl-5-AMiobenzenesulfonMide;

Molecular Formula: C7H10N2O2S


Molecular Weight: 186.23

Pharmacopeia: In house Spec.

Specifications:Available on request

Packing:Export worthy packing

Material Safety Data Sheet:Available on request

Pazopanib Intermediate lists:

2,3-Dimethyl-2H-indazol-6-amine, CAS  444731-72-0

2,3-DIMETHYL-6-NITRO-2H-INDAZOLE,CAS 444731-73-1   

3-methyl-6-nitro-2H-indazole CAS number  1313372-75-6

2-Ethyl-5-nitrobenzenamine, CAS numbe  20191-74-6.

2-Methyl-5-AMiobenzenesulfonmide CAS 6973-09-7,

2-methyl-5-nitrobenzenesulfonamide  CAS number 6269-91-6,

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