|Min. Order:||1 Kilogram|
|Delivery Time:||15 Days|
Model No.: 448-19-1
Packaging: AS REQUIRED
Place of Origin: CHINA
Supply Ability: TRUE MANUFACTURER
5-fluoro-2-nitroanisole CAS number is 448-19-1, which is the starting material for the synthesis of Osimertinib, 5-fluoro-2-nitroanisole by amine hydrolysis, reduction, nitration, and then The Lewis acid reacts, reacts with N-methyl hydrazine, reductively reduces the nitro group, and amidates to get the product, and finally forms a salt to obtain Osimertinib. 5-fluoro-2-nitroanisole is involved in the amination process: weigh 50g of 5-fluoro-2-nitroanisole into a three-necked flask equipped with a thermometer, add 300ml of DMF, and heat up to 85℃, After stirring for 10 min, 31.4 g of N,N,N'-trimethylethylenediamine was added dropwise, and the mixture was stirred for 4 hours. After the reaction was completed, 600 ml of water was added dropwise. After stirring for 3 hours, a yellow solid was obtained by filtration.
5-Fluoro-2-nitroanisole CAS number 448-19-1 can also be used to synthesize meta-hydroxy or methoxy polybrominated diphenyl ethers. The 5-fluoro-2-nitroanisole is subjected to a coupling reaction, a nitro reduction reaction, a deamination reaction, a demethylation reaction, and a bromine substitution reaction to finally obtain a meta-hydroxyl/methoxy polybrominated diphenyl ether. The first step of the coupling reaction involving 5-fluoro-2-nitroanisole is as following: 5-fluoro-2-nitroanisole, 2,4-dibromophenol, anhydrous Na2CO3 at molar ratio of 1.3:1:1, dissolved in the solvent N,N-dimethylacetamide, and the reaction is refluxed for 1.5 to 2.5 hours to obtain a first-phase coupling product.
Thera. Category: Fluorine-Containing chemical
Cas No.: 448-19-1
Synonym: 4-FLUORO-2-METHOXY-1-NITROBENZENE;5-Fluoro-2-nitroanisole99%;5-Fluoro-2-nitroanis;5-Fluoro-2-nitrophenyl methyl ether;2-Nitro-5-Fluoro Anisole;1-Fluoro-3-Methoxy-4-nitrobenzene;5-FLUORO-2-NITROANISOL;5-FLUORO-2-NITROANISOLE;
Molecular Formula: C7H6FNO3
Molecular Weight: 171.13
Packing:Export worthy packing
Material Safety Data Sheet:Available on request