5-HT3 Antagonist Palonosetron Hydrochloride CAS Number 135729-62-3

Unit Price: USD 1.0000 / Kilogram
Payment Type: T/T
Incoterm: CIF
Min. Order: 1 Kilogram
Delivery Time: 15 Days

Basic Info

Model No.: 135729-62-3

Function: Nervous System Drugs

Additional Info

Packaging: AS REQUIRED

Productivity: KGS


Transportation: Air

Place of Origin: CHINA


Product Description

Palonosetron Hydrochloride CAS Number is 135729-62-3, which is a suppressor of nausea and vomiting, belongs to a new high selectivity, high affinity 5-HT3 receptor antagonist that blocks the synapses of vomiting reflex central peripheral neurons Former 5-HT. Clinically for the treatment of acute, delayed nausea and vomiting caused by moderate and severe emetic chemotherapy. Because of its high efficacy, side effects, long half-life (about 40 h), the dosage is small and so on. Clinical studies have shown that palonosetron CAS 135729-62-3 can safely be used with corticosteroids, analgesics, antiemetics, antispasmodic and anticholinergic drugs. Rat tumor model studies have shown that palonosetron does not inhibit the anticancer activity of the five chemotherapeutic agents studied, such as cisplatin, cyclophosphamide, cytarabine, doxorubicin and mitomycin C.
Palonosetron Hydrochloride CAS Number 135729-62-3 was first approved by the US Food and Drug Administration in 2003 and subsequently approved by the European Medicines Agency in 2005 and was approved by the Japanese Medical and Pharmaceutical Equipment Consortium in 2010. It is the fourth approved 5-HT3 receptor antagonist, whose important feature is long half-life, other 5-HT3 receptor antagonists half-lives only for a few hours, and palonosetron hydrochloride is about 40 hours, and The affinity to the receptor is almost 100 times that of other 5-HT3 antagonists. It overcomes the shortcomings of Ondansetron, Dolasetron and Granisetron that need to be administered at different stages, improving patient compliance.

Thera. Category: antiemetic and antinauseant agent.

Cas No.:  135729-62-3

Synonyms:PALONOSETRON HCL;PALONOSETRON HYDROCHLORIDE; Aloxi;Onicit;RS-25259-197;(S,S)-Palonosetron Hydrochloride


Molecular Formula:C19H25ClN2O

Molecular Weight:332.87

Purity: ≥98%

Packing: Export worthy packing

Material Safety Data Sheet: Available on request

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