848133-35-7,Trans 4-Dimethylaminocrotonic Acid Hydrochloride

Unit Price: USD 2000.0000 / Kilogram
Payment Type: T/T
Incoterm: CIF
Min. Order: 1 Kilogram
Delivery Time: 15 Days

Basic Info

Model No.: 848133-35-7

Additional Info

Packaging: AS REQUIRED

Productivity: KGS


Transportation: Air,DHL

Place of Origin: CHINA


Certificate: ISO

Product Description

Trans 4-Dimethylaminocrotonic acid hydrochloride Cas number 848133-35-7 is for making Afatinib,Molecular formulais C6H12ClNO2. It belongs to a kind of amino crotonic acid derivatives,has a wide range of application in the synthesis of anti-tumor drugs.One of the most common is for the synthesis of Afatinib and Neratini.It reacts mainly with the corresponding intermediates by activation of the amide linker to get afatinib.It has a lot of preparation methods, but most of them existing environmental pollution defects. We can use diethyl malonate and 2,2-Diethoxy-N,N-dimethylethylamine as the starting material through three steps reaction to get the Afatinib side chain Cas number 848133-35-7, this method has obvious advantages, with low production costs, environmental pollution is small, Easy to operate. Our production of afatinib side chain is mainly provide supporting production services to the domestic large pharmaceutical factory with afatinib mother nucleus , our workshops and regulatory documents have passed a large pharmaceutical factory strict audit in several times from time to time.

Thera. Category:Anti- cancer

Cas No.:848133-35-7

Synonym:Afatinib intermediate E;(2E)-4-(diMethylaMino)but-2-enoic acid hydrochloride;(e)-4-(dimethylamino)-2-butenoic acid hydrochloride;trans-4-Dimethylaminocrotonic acid hydrochloride;TRANS-4-DIMETHYLAMINOCROTONIC ACID HCL;2-BUTENOIC ACID, 4-(DIMETHYLAMINO)-, HYDROCHLORIDE;(E)-4-(dimethylamino)but-2-enoic acid hydrochloride;4-DiMethylaMino-But-2-Enoic Acid Hcl Salt;

Molecular Formula: C6H12ClNO2


Molecular Weight: 165.62

Assay: ≥98.%

Packing: Export worthy packing

Material Safety Data Sheet: Available on request

Usage: Intermediate of Afatinib

Related Intermediates :
1. CAS 162012-69-3, 7-Fluoro-6-nitro-4-hydroxyquinazoline
2. CAS 16499-57-3, 7-Fluoroquinazolin-4(3H)-one

         3CAS 162012-67-1, 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro- ,

        4. Trans 4-Dimethylaminocrotonic acid hydrochloride Cas number 848133-35-7 

Active Pharmaceutical Ingredients> Cas 90098-04-7,Rebamipide Named In Mucosta With GMP Standard
Active Pharmaceutical Ingredients> Functional Dyspepsia Treatment Acotiamide Hydrochloride Trihydrate CAS 773092-05-0
Active Pharmaceutical Ingredients> Acotiamide Hydrochloride For Gastric Motility Improvement CAS 185104-11-4
Contract Manufacturing> ASCORBYL GLUCOSIDE Used for Comesitc Additive CAS 129499-78-1
Pharmaceutical Intermediates> Anti-Ulcerative> 2-Aminothiazole-4-ethylformate For Making Acotiamide Cas 5398-36-7
Pharmaceutical Intermediates> Anti-Ulcerative> Acotiamide INT CAS NUMBER 185105-98-0
Pharmaceutical Intermediates> Anti-Cardiovascular> Azilsartan Used for Hypertension Treatment CAS 147403-03-0
Pharmaceutical Intermediates> Anti-Diabetes> Sitagliptin Phosphate Monohydrate Treated for Type 2 diabetes CAS Number 654671-77-9
Pharmaceutical Intermediates> Anti-Ulcerative> Cas 132210-24-3, 2-Amino-3-(1,2-dihydro-2-oxo-quinoline-4-yl)Propanoic acid Hydrochloride For Rebamipide
Pharmaceutical Intermediates> Anti-Ulcerative> Cas 1068-90-2 White Crystalline Powder Diethyl Acetamidomalonate For Rebamipide(DAAM)
Active Pharmaceutical Ingredients> 6027-23-2, Hordenine HCL Powder
Pharmaceutical Intermediates> Anti-Ulcerative> Cas 4876-10-2,4-Bromomethyl-2(1H)-quinolinone (BMQ) For Rebamipide/ Mucosta
Pharmaceutical Intermediates> Anti-Respiratory> CAS 2338-18-3, 2-Aminoindan hydrochloride For Making Indacaterol
Pharmaceutical Intermediates> Anti-Respiratory> CAS 312753-53-0/ 5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride Used for Indacaterol
Pharmaceutical Intermediates> Anti-Respiratory> 312753-53-0, Indacaterol Intermediate
Pharmaceutical Intermediates> Anti-Respiratory> 100331-89-3, Indacaterol Intermediate

© 2019 CHINA WAY. All Rights Reserved.  Taizhou Volsen Chemical Co., Ltd.,  Inc.   All rights reserved. site map.  sitemap.html