|Min. Order:||1 Gram|
|Delivery Time:||20 Days|
Model No.: 1005450-55-4
Packaging: AS REQUIRED
Place of Origin: CHINA
Supply Ability: COMMERCIAL PRODUCTION
We are professional N-((R)-1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoroMethyl)phenyl)propanamide CAS 1005450-55-4 supplier in China. It is an important intermediates for Cinacalcet HCl. Cinacalcet as a calcimimetic drug apply to parathyroid carcinoma. The Cinacalcet HCl Intermediates CAS NO 1005450-55-4 is white powder with the molecular formula of C22H20F3NO and formula weight 371.3955096. We can offer fast delivery and best service
Usage: Cinacalcet(AMG-073) is an orally active, second-generation calcimimetic compound; AMG 073 represents a new class of compounds for the treatment of hyperparathyroidism.Cinacalcet is the only calcimimetic approved for HPT secondary to chronic kidney disease (CDK), parathyroid carcinoma, and, in some countries, primary HPT. Clinical trials showed that cinacalcet reduced PTH and calcemia both in CDK and primary HPT, lowering the risk of bone fractures, surgery, and cardiovascular complications in the former patients. Long-term safety and pharmacoeconomics have to be fully tested yet. Few both in vitro and in vivo studies showed an association between Arg990Gly-CASR polymorphism and cinacalcet sensitivity, though in patients with severe CASR inactivating mutations the drug substantially retained its positive clinical effects.