Anti-histamine & Anti-allergic Drug Mizolastine Cas Number 108612-45-9

Payment Type: L/C,T/T
Incoterm: FOB
Min. Order: 1 Kilogram
Delivery Time: 15 Days

Basic Info

Model No.: 108612-45-9

Additional Info

Packaging: AS REQUIRED

Productivity: KGS


Transportation: Air

Place of Origin: CHINA


Certificate: ISO

Product Description

Mizolastine cas number is 108612-45-9 which is a specific and selective peripheral histamine H1 receptor antagonist with anti-histamine and anti-allergic activity. For seasonal and perennial allergic nasal itch, allergic conjunctivitis, urticaria and other allergic symptoms. Mizolastine orally absorbed rapidly, the plasma concentration peak time of 1.5 hours, bioavailability of 65% for the linear metabolic kinetics. The average elimination half-life was 13.0 hours and the plasma protein binding rate was 98.4%. Mizolastine in patients with liver dysfunction absorbed more slowly, with a longer distribution and a moderate increase in AUC (approximately 50%). The main metabolic pathway is the glucuronidation of the parent compound. Cytochrome P4503A4 enzyme system is also involved in the hydrolytic metabolism of this product. The known metabolites have no pharmacological activity. Mizolastine has a unique dual antihistamine and anti-allergic response to inflammatory mediators. In vivo and in vitro pharmacological tests have shown that mizolastine is a potent and highly selective histamine H1 receptor antagonist. Mizolastine cas number  108612-45-9 also inhibits the release of histamine from activated mast cells and suppresses the chemotaxis of inflammatory cells such as neutrophils in an animal model of allergic reaction. At the same time, mizolastine also inhibits the release of intercellular adhesion molecule-1 during allergy. Pharmacological tests showed that mizolastine has anti-inflammatory activity, which may be related to its inhibitory effect on 5-lipoxygenase.

Thera. Category:anti-histamine and anti-allergic 

Cas No.: 108612-45-9

Synonym: lndobufen;INDOBNFEN;2-[4-(1-oxo-2-isoindolinyl)phenyl]butyric acid


Molecular Weight:  432.49

Molecular formula:C24H25FN6O

Assay: ≥98.%

Appearance: White Crystalline solid

Packing:Export worthy packing

Material Safety Data Sheet:Available on request

Active Pharmaceutical Ingredients> Cas 90098-04-7,Rebamipide Named In Mucosta With GMP Standard
Active Pharmaceutical Ingredients> Functional Dyspepsia Treatment Acotiamide Hydrochloride Trihydrate CAS 773092-05-0
Active Pharmaceutical Ingredients> Acotiamide Hydrochloride For Gastric Motility Improvement CAS 185104-11-4
Contract Manufacturing> ASCORBYL GLUCOSIDE Used for Comesitc Additive CAS 129499-78-1
Pharmaceutical Intermediates> Anti-Ulcerative> 2-Aminothiazole-4-ethylformate For Making Acotiamide Cas 5398-36-7
Pharmaceutical Intermediates> Anti-Ulcerative> Acotiamide INT CAS NUMBER 185105-98-0
Pharmaceutical Intermediates> Anti-Cardiovascular> Azilsartan Used for Hypertension Treatment CAS 147403-03-0
Pharmaceutical Intermediates> Anti-Diabetes> Sitagliptin Phosphate Monohydrate Treated for Type 2 diabetes CAS Number 654671-77-9
Pharmaceutical Intermediates> Anti-Ulcerative> Cas 132210-24-3, 2-Amino-3-(1,2-dihydro-2-oxo-quinoline-4-yl)Propanoic acid Hydrochloride For Rebamipide
Pharmaceutical Intermediates> Anti-Ulcerative> Cas 1068-90-2 White Crystalline Powder Diethyl Acetamidomalonate For Rebamipide(DAAM)
Active Pharmaceutical Ingredients> 6027-23-2, Hordenine HCL Powder
Pharmaceutical Intermediates> Anti-Ulcerative> Cas 4876-10-2,4-Bromomethyl-2(1H)-quinolinone (BMQ) For Rebamipide/ Mucosta
Pharmaceutical Intermediates> Anti-Respiratory> CAS 2338-18-3, 2-Aminoindan hydrochloride For Making Indacaterol
Pharmaceutical Intermediates> Anti-Respiratory> CAS 312753-53-0/ 5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride Used for Indacaterol
Pharmaceutical Intermediates> Anti-Respiratory> 312753-53-0, Indacaterol Intermediate
Pharmaceutical Intermediates> Anti-Respiratory> 100331-89-3, Indacaterol Intermediate

© 2019 CHINA WAY. All Rights Reserved.  Taizhou Volsen Chemical Co., Ltd.,  Inc.   All rights reserved. site map.  sitemap.html