Avanafil Intermediate 4, CAS 41965-95-1

Unit Price: USD 1.0000 / Kilogram
Payment Type: T/T
Incoterm: CIF
Min. Order: 1 Kilogram
Delivery Time: 15 Days

Basic Info

Model No.: 41965-95-1

Function: Nervous System Drugs

Additional Info

Packaging: AS REQUIRED

Productivity: KGS


Transportation: Air

Place of Origin: CHINA


Port: Beijing,Shanghai,Shenzhen

Product Description

Avanafil Intermediate 4 CAS number is 41965-95-1,chemical name is 3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDE, Molecular formula C8H11Cl2NO, Molecular weight 208.09. According relevant information recorded, use ethyl 4, 4-dichloropyrimidine-5-carboxylate as raw material, add avanafil intermediate 4 to take Substitution reaction to get the corresponding compounds, Through two-step reaction, Avanafil API was obtained. But we found a problem in the substitution of 2,4-position,two chlorine in the selectivity is not strong,it is easy to cause the content of isomers become larger, affecting product quality. So we think this method is not desirable. There is a way we think more reliable, that is take proline ester hydrochloride and oxymethylisourea salt in the alcohol solvent ammonia reaction occurred to get the corresponding intermediates, and then by 2-step reaction to get the relevant intermediates,then adding Avanafil intermediate,Fenafloxacin 4,take the substitution reaction to obtain the corresponding avanafil advanced intermediates, which is the best entry point for the use of avanafil intermediate 4, which allows the early introduction of side chains of avanafil, It is possible to avoid the use of costly chiral proline feedstocks and to avoid the use of selective substitution reactions at the 2,4-position and the use of peroxides to introduce the five-membered side chain.

Thera. Category:   Erectile Dysfunction Treatment

Cas No.: 41965-95-1

Synonyms:BIO-FARMA BF004393;3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDE;4-AMINOMETHYL-2-CHLOROANISOLE HCL;4-AMINOMETHYL-2-CHLOROANISOLE HYDROCHLORIDE;3-chloro-4-methoxybenzylamineHCl;3-Chloro-4-methoxybenzylamineHCl95%;3-Chloro-4-methoxybenzylaminehydrochloride95%;3-Chloro-4-methoxybenzylamine hydrochloride 95%


Molecular Formula:C8H11Cl2NO

Molecular Weight:208.09

Purity: ≥98%

Packing: Export worthy packing

Material Safety Data Sheet: Available on request

Related intermediate:


2) 5909-24-0,EthAvanafil CAS  330784-47-9

3) Avanafil intermediate 3 CAS number  330785-81-4

4) 2-aminomethylpyrimidine hydrochloride  CAS 372118-67-7,


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