CAS 1051375-13-3, Cabotegravir Sodium

Unit Price: USD 1.0000 / Kilogram
Incoterm: CIF
Min. Order: 1 Kilogram
Delivery Time: 15 Days

Basic Info

Model No.: 1051375-13-3

Additional Info

Packaging: As required

Productivity: 10KG/M

Brand: VOLSENCHEM

Transportation: Air

Place of Origin: CHINA

Supply Ability: In stock

Certificate: Technical Support

Product Description

1051375-13-3, Cabotegravir Sodium, GSK1265744 (SodiuM Salt)

l Thera. Category: anticholinergic, used in the treatment of Chronic obstructive pulmonary disease.

l Cas No.: 1051375-13-3

l Synonym: GSK1265744 (sodiuM salt);Cabotegravir Sodium

l Molecular Formula: C19H17F2N3NaO5+

1051375-13-3

l Molecular Weight: 428.34

l Assay: ≥98.%

l Packing: Export worthy packing

l Material Safety Data Sheet: Available on request

l Usage: Cabotegravir Sodium,GSK744 (S/GSK1265744) is a potential inhibitor of HIV integrase with IC50 value of 3 nM [1].
HIV integrase is an enzyme produced by HIV virus that enables its genetic material to be integrated into the infected cell DNA. It is reported that HIV intergrase inhibitor plays an important role in halting HIV progression [2].
GSK744 (S/GSK1265744) is a potent HIV integrase inhibitor. Using resistance passage experiments, integrase enzyme assays, and cellular assays with site-directed molecular (SDM) HIV clones resistant to other classes of anti-HIV-1 agents and earlier integrase strand transfer inhibitors, results showed that GSK1265744 efficiently inhibited HIV replication through inhibiting HIV integrase [1]. 

We are availabe for several Intermediates of Cabotegravir:

1) 1335210-24-6, Oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxylic acid, 2,3,5,7,11,11a-hexahydro-6-methoxy-3-methyl-5,7-dioxo-, (3S,11aR)

2) 1335210-25-7, (3S,11aR)-N-(2,4-difluorobenzyl)-6-methoxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydrooxazolo[3,2-d]pyrido[1,2-a]pyrazine-8-carboxamide

3) 1051375-10-0, Cabotegravir Free Acid

4) 1051375-13-3, Cabotegravir Sodium

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