CAS 189188-57-6,Tegaserod Maleate

Unit Price: USD 916.0000 - 950.0000 / Kilogram
Payment Type: T/T
Incoterm: CIF
Min. Order: 1 Kilogram
Delivery Time: 7 Days

Basic Info

Model No.: 189188-57-6

Additional Info

Packaging: AS REQUIRED

Productivity: 20KGS/M

Brand: VOLSENCHEM

Transportation: Air

Place of Origin: CHINA

Supply Ability: IN Stock

Certificate: GMP Environment

Product Description

We,ChinaTegaserod Maleate Suppliers and China 22795-99-9 Tegaserod Maleate Cas No.189188-57-6


Manufacturers with quality you can count on including those with CAS number189188-57-6, You can be assured that all Tegaserod Maleate 189188-57-6 offered by Volsen, meet or exceed the grade requirements or specifications for each individual product.

  • Thera. Category:Gastrointestinal Agents
  • Cas No.:189188-57-6
  • Synonym:(2E)-2-[(5-Methoxy-1H-indol-3-yl)methylene]-N-pentylhydrazinecarboximidamide
  • Molecular Formula:C20H27N5O5
189188-57-6
  • Molecular Weight:417.
  • Pharmacopeia: in house spe.
  • Specifications:Available on request
  • Packing:Export worthy packing
  • Material Safety Data Sheet:Available on request

Usage: 1.A gastroproeinetic use in the treatment of irritable bowel syndrome.
2.A selective serotonin 5HT4-receptor partial agonist

COA Specification of Tegaserod Maleate Cas No.189188-57-6

Items

Specifications

Results

Appearance

A White powder

Conform

Identification

HPLC

IR

Conform

Solubility

Scarcely soluble in water, sparingly soluble in methanol, slightly soluble in ethanol and scarcely soluble in chloroform

Conform

Methanol

0.30%

Conform

Melting Point

188.0°C ~193.0°C

188.5°C~190.5°C

Loss on drying

0.50%

0.16%

Residual on ignition

0.10%

0.07%

Heavy Metals

10ppm

Conform

Residual solvent

Ethanol5000ppm

Methanol3000ppm

Conform

Conform

Related Substances(HPLC)

Single impurity0.3%

Total impurities1.0%

0.08%

0.13%

Assay(based on drying)

99.0

99.3%

Particle size

50%70microns

90%205microns

Conform

Conform

Conclusion: The product corresponds to the requirements of in house standard.

Storage Condition: Keep container tightly closed in a dry and well-venting place.


Tegaserod is a 5-HT4 agonist manufactured by Novartis and sold under the name Zelnorm for the management of irritable bowel syndrome and constipation.

Mechanism of action

The drug functions as a motility stimulant, achieving its desired therapeutic effects through activation of the 5-HT4 receptors of the enteric nervous system in the gastrointestinal tract. It also stimulates gastrointestinal motility and the peristaltic reflex, and allegedly reduces abdominal pain. Additionally, tegaserod is a 5-HT2B receptor antagonist.

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