Cas 209216-23-9,High Purity Entecavir Monohydrate(Mirconized)

Unit Price: USD 47.0000 - 65.0000 / Gram
Payment Type: L/C,T/T
Incoterm: CIF
Min. Order: 1 Gram
Delivery Time: 7 Days

Basic Info

Model No.: 209216-23-9

Function: Disinfectant and Preservatives

Additional Info

Packaging: Export worthy packing

Productivity: 50KG/Y

Brand: VOLSENCHEM

Transportation: Ocean,Air

Place of Origin: CHINA

Supply Ability: Immediately

Certificate: DMF OPEN PART

Product Description

We are enable to supply two type of entecavir: mirconized power/common power.


Entecavir monohydrate(209216-23-9) is a nucleoside analog(more specifically, a guanine analogue) that inhibits reverse transcription, DNA replication and transcription in the viral replication process.

Thera. Category: Adult chronic hepatitis B

Cas No.:209216-23-9

Synonym:entecavir hydrate;ENTECAVIR MONOHYDRATE;2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one monohydrate;Entecavir hydrate / 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one monohydrate

Molecular Formula:C12H17N5O4


Molecular Weight:295.29448

Pharmacopeia: In house Spec.

Specifications:Available on request

Packing:Export worthy packing

Material Safety Data Sheet:Available on request

Usage:This product is applicable to the treatment of adult chronic hepatitis B.

CERTIFICATE OF ANALYSIS

Product Name

Entecavir Monohydrate

Cas No.

209216-23-9

Producing Date

2014-10-03

Batch No.

20141003

Assaying Date

2014-10-03

Reporting Date

2014-10-03

Expiry Date

2016-10

Quantity

50Gram


Items

Specifications

Results

Appearance

White or off-white powder

White powder

Identification

1)The IR absorption specturm of the sample must be same with entecavir

2) RT of the sample should match that of standard assay preparation

Comform

Water

5.8%~6.5%

6.1%

Optical rotation

+24°~+28° (DMF:MOH=1:1 C=1%)

+27.2°

Residue on ignition

≤0.10%

0.07%

Heavy Metals

20ppm

Conforms

Related substances

Total impurities

≤0.30%

0.07%

Single impurity

≤ 0.1%

0.03%

Residual solvents

dichloromethane

600ppm

100PPM

methanol

1000ppm

300PPM

tetrahydrofuran

700ppm

ND

toluene

600ppm

ND

Assay (HPLC)

99.8% ~102.0%(On anhydrous basis)

≥99.9%

Particle size

D9030um

Conform

Conclusion: The product corresponds to the requirements of in house standard.


Related intermediates:

1)2-Amino-6-Benzyloxypurine 19916-73-5

2)(1S,2R,3S,5R)-3-(Phenymethyloxy)-2-(phenylmethoxy)methyl-6-oxabicyclo[3.1.0]hexane 110567-22-1

3)(1S,2S,3S,5S)-5-(2-Amino-6-(benzyloxy)-9H-purin-9-yl)-3-(benzyloxy)-2-(benzyloxymethyl)cyclopentanol 142217-77-4

4)(2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-(phenylmethoxy)-9H-purin-9-yl]-2-(benzyloxymethyl)cyclopentanol 142217-78-5

5)2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one CAS 142217-81-0

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