Cas 3680-69-1, 4-Chloropyrrolo[2,3-d]pyrimidine Used for making Tofacitinib

Payment Type: T/T
Incoterm: FOB
Min. Order: 1 Gram
Delivery Time: 10 Days

Basic Info

Model No.: 3680-69-1

Additional Info

Packaging: As Required

Productivity: 1kgs, 2kgs,....


Transportation: Air

Place of Origin: CHINA

Product Description

4-Chloropyrrolo[2,3-d]pyrimidine cas number 3680-69-1 is a tofacitinib intermediate for the treatment of methotrexate insufficiency or intolerance of moderate to severe rheumatoid arthritis drug , as well as intermediates commonly used in the synthesis of benzamide c-Met kinase inhibitors. There are two synthetic routes of 4-Chloropyrrolo[2,3-d]pyrimidine, one is usd ethyl cyanoacetate, thiourea, sodium ethoxide as raw materials, and the other is use 2,4-dichloro-7H pyrrolidine as raw material. We have a mature process for both routes.


4-Chloropyrrolo[2,3-d]pyrimidine/Tofacitinib Intermediates





Molecular Weight:


Molecular structure:

CAS 3680-69-1



Boiling point:

332.5°C at 760 mmHg

Flash point:


Vapor Pressure:

0.000145mmHg at 25°C

Tofacitinib intermediates, it is our major new project, enable to supplying all kinds of intermediates in high quality.

Related Intermediates:

1. 3680-69-1 4-Chloropyrrolo[2,3-d]pyrimidine

2. 479633-63-1 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

3. 90213-66-4 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine


5. 32018-96-5 1-benzyl-4-methylpiperidin-3-one

6. 477600-75-2, Tofactinib base

7. 540737-29-0, Tofacitnib Citrate

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