|Min. Order:||1 Gram|
|Delivery Time:||20 Days|
Model No.: 875573-66-3
Packaging: AS REQUIRED
Place of Origin: CHINA
On the preparation of this Intermediate of Fulvestrant cas number 875573-66-3, most manufacturers use nandrolone as the starting material, there are a small number of manufacturers using estradiol as raw materials. The preparation process first reacted with estradiol and 3,4-dihydropyran catalyzed by p-toluenesulfonic acid. The product was then reacted with trimethyl borate / H2O2 to produce alcohol hydroxyl groups at the 6-position of steroids,And then oxidized with pyridinium chlorochromate to form ketone carbonyl compounds, and the ketone carbonyl compound use potassium tert-butoxide as soda, take the nucleophilic substitution reaction of C2F5 (CH2) 3S (CH2) 9Br and then the product was further treated with BF3Et2O / Et3SiH to remove 6-position Carbonyl, the pyran protecting group was removed by hydrolysis using K2CO3 to give the target compound Fulvestrant intermediate 875573-66-3. The biggest drawback of this preparation method is that waste water contains a lot of heavy metals which is difficult to handle, wastewater discharge is difficult to meet environmental requirements.
We are offering in wide range of Pharmaceutical Intermediates CAS 875573-66-3,(7a,17b)-7-(9-Bromononyl)-Estra- 1,3,5(10)-Triene-3,17-Diol 17-Acetate which is an intermediate of Fulvestrant.These high quality products are formulated by adopting quality methods and using well-tested ingredients that are procured from the certified vendors of the market. We offer these products in proper packaging of diverse quantity to meet assorted requirements of the clients.
Usage: Intermediate of Fulvestrant
We are available for following Fulvestrant intermediate:
2)CAS 875573-66-3,(7a,17b)-7-(9-Bromononyl)-Estra- 1,3,5(10)-Triene-3,17-Diol 17-Acetate
3CAS 875573-69-6),(7a,17b)-7-[9-[(4,4,5,5,5-Pentafluoropentyl)Thio]Nonyl]-Estra-1,3,5(10)-Triene- 3,17-Diol 17-Acetate