CAS 875573-66-3,Fulvestrant Intermediate (7a,17b)-7-(9-Bromononyl)-Estra- 1,3,5(10)-Triene-3,17-Diol 17-Acetate

Payment Type: T/T
Incoterm: CIF
Min. Order: 1 Gram
Delivery Time: 20 Days

Basic Info

Model No.: 875573-66-3

Additional Info

Packaging: AS REQUIRED

Productivity: G,KGS,


Transportation: Air

Place of Origin: CHINA

Product Description

On the preparation of this Intermediate of Fulvestrant cas number 875573-66-3, most manufacturers use nandrolone as the starting material, there are a small number of manufacturers using estradiol as raw materials. The preparation process first reacted with estradiol and 3,4-dihydropyran catalyzed by p-toluenesulfonic acid. The product was then reacted with trimethyl borate / H2O2 to produce alcohol hydroxyl groups at the 6-position of steroids,And then oxidized with pyridinium chlorochromate to form ketone carbonyl compounds, and the ketone carbonyl compound use potassium tert-butoxide as soda, take the nucleophilic substitution reaction of C2F5 (CH2) 3S (CH2) 9Br  and then the product was further treated with BF3Et2O / Et3SiH to remove 6-position Carbonyl, the pyran protecting group was removed by hydrolysis using K2CO3 to give the target compound Fulvestrant intermediate 875573-66-3. The biggest drawback of this preparation method is that waste water contains a lot of heavy metals which is difficult to handle, wastewater discharge is difficult to meet environmental requirements.

We are offering in wide range of Pharmaceutical Intermediates CAS 875573-66-3,(7a,17b)-7-(9-Bromononyl)-Estra- 1,3,5(10)-Triene-3,17-Diol 17-Acetate which is an intermediate of Fulvestrant.These high quality products are formulated by adopting quality methods and using well-tested ingredients that are procured from the certified vendors of the market. We offer these products in proper packaging of diverse quantity to meet assorted requirements of the clients.

  • Thera. Category:Anti-breast cancer
  • Cas No.:875573-66-3
  • Synonym:(7a,17b)-7-(9-Bromononyl)-estra-1,3,5(10)-triene-3,17-diol 17-acetate;Estra-1,3,5(10)-triene-3,17-diol,7-(9-broMononyl)-,17-acetate,(7a,17b)-;(7R,8R,9S,13S,14S,17S)-7-(9-Bromononyl)-3-hydroxy-13-methyl-7,8,9,11, 12,13,14,15,16,17-decahydro;(7a,17b)-7-(9-BroMononyl)-estra-1,3,5(1)-triene-3,17-diol 17-acetate;(7R,8R,9S,13S,14S,17S)-7-(9-BroMononyl)-3-hydroxy-13-Methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl acetate
  • Molecular Formula:C29H43BrO3
  • 875573-66-3
  • Molecular Weight:519.55
  • Specifications:Available on request
  • Packing:Export worthy packing
  • Material Safety Data Sheet:Available on request

Usage: Intermediate of Fulvestrant

We are available for following Fulvestrant intermediate:

1)CAS 875573-63-0,(7alpha,17beta)-17-(Acetyloxy)-7-(9-bromononyl)estr-4-en-3-one

2)CAS 875573-66-3,(7a,17b)-7-(9-Bromononyl)-Estra- 1,3,5(10)-Triene-3,17-Diol 17-Acetate

3CAS 875573-69-6),(7a,17b)-7-[9-[(4,4,5,5,5-Pentafluoropentyl)Thio]Nonyl]-Estra-1,3,5(10)-Triene- 3,17-Diol 17-Acetate

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