Cetilistat Alt-962 Intermediate CAS 282526-98-1

Payment Type: L/C,T/T
Incoterm: FOB
Min. Order: 1 Kilogram
Delivery Time: 15 Days

Basic Info

Model No.: 282526-98-1

Function: Nutritional Therapeutics

Grade Standard: Medicine Grade

State: Solid

Volatile: Not Volatile

Additional Info

Packaging: AS REQUIRED

Productivity: KGS


Transportation: Air

Place of Origin: CHINA


Certificate: ISO

Product Description

As we all known, Cetilistat (Alt-962) CAS 282526-98-1 is a novel lipase inhibitor for the treatment of obesity in both diabetic and non-diabetic patients. Cetilistat 282526-98-1 acts by inhibiting pancreatic lipase, an enzyme that breaks down triglycerides in the intestine. We can offer Alt-962 CAS NO 282526-98-1 range from gram grade to kilogram grade. Cetilistat is designed to treat obesity, customers can take use of this properties according to their needs.

Cetilistat cas number 282526-98-1 which is a very safe new weight loss drugs. Its synthesis methods are mainly the following: Firstly,Take the reaction of 2-amino-5-methylbenzoic acid with cetyl chloroformate, achieves the purpose of aminoacylation, carboxylation and cyclization in one step. Although the process seems simple, it requires a substantial excess of chlorine Formic acid hexadecyl ester to complete these conversions, and the yield is very low only 20%.Secondly, with p-methyl phenyl isocyanate as the starting material and react with cetyl alcohol to get hexadecyl p-tolyl carbamate, and then process benzene ring bromide reaction with bromine, under the catalyzed of  Trans-Dichlorobis(triphenyl-phosphine)Palladium, adding carbon monoxide, water and halogenated aromatic ring condensation into the carboxyl group, and then under the action of ethyl chloroformate ring to get the Cetilistat cas number 282526-98-1 . The palladium catalyst used in this method is expensive, and there are existing several disadvantages of many waste discharge, harsh reaction conditions , and high required on the equipment. Thirdly, with pyridine as solvent and acid, react with 2-amino-5-methyl benzoic acid and slightly excess of cetyl chloroformate, and then adding phosphorus oxychloride for intramolecular ring to get Cetilistat cas 282526-98-1, the method compare to before two methods,the yields is the highest, reaching to 90%, but it has shortcoming that there are a lot of use of strong irritant reagents pyridin. Some people adjusted the methods, the two starting materials are unchanged,then process amino acid acylation, purify the intermediate and then cyclization, through the two-step reaction to the target compound, this method can significantly reduce the use amount of pyridine, the yield can reach more than 90%.
Thera. Category:Treat Obesity

Cas No.: 359-13-7

Synonym: cetilistat;Cetilistat(Alt-962);Cetilstat;2-(Hexadecyloxy)-6-methyl-4H-3,1-benzoxazin-4-one;2-(Hexadecycloxy)-6-methyl-4H-3,1-benzoxazin-4-one;4H-3,1-Benzoxazin-4-one,2-(hexadecyloxy)-6-Methyl-;Xinli orlistat


Molecular Weight: 401.58

Molecular formula: C25H39NO3

Assay: ≥98.%

Appearance: White Crystalline solid

Packing:Export worthy packing

Material Safety Data Sheet:Available on request


Cetilistat is a drug designed to treat obesity. It acts in the same way as the older drug orlistat (Xenical) by inhibiting pancreatic lipase, an enzyme that breaks down triglycerides in the intestine. Without this enzyme, triglycerides from the diet are prevented from being hydrolyzed into absorbable free fatty acids and are excreted undigested

Cetilistat intermedates:

2,2-Difluoroethanol CAS 359-13-7

4-Fluoro-2-Methoxyaniline CAS 450-91-9

3-Pyridinecarboxylic acid, 6-amino- CAS 3167-49-5

5-Bromo-1,3-Dichloro-2-Fluorobenzene CAS 17318-08-0

Methyl 6-Aminonicotinate(Cetilistat Intermediate) CAS 36052-24-1

4-Fluoro-3-Nitroanisole (Cetilistat, Alt-962 Intermediate) CAS 61324-93-4

2-(Hexadecyloxy)-6-methyl-4H-3,1-benzoxazin-4-one CAS 282526-98-1

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