Diethylphosphoacetic Acid For Making Afatinib CAS number 3095-95-2

Basic Info

Model No.: 3095-95-2

Additional Info

Packaging: AS REQUIRED

Productivity: KGS

Brand: VOLSENCHEM

Transportation: Air,DHL

Place of Origin: CHINA

Supply Ability: TRUE MANUFACTURER

Certificate: ISO

Product Description

Diethylphosphoacetic acid CAS number 3095-95-2, Appearance is a transparent or yellow viscous liquid,it can be used to synthesize afatinib and can also be used to provide phosphonate intermediates for intramolecular HEW reactions.The synthesis is easy,it is not necessary to do the corresponding introduction. At present, there is no literature about the analysis of diethyl phosphoacetic acid. In order to ensure the quality of R & D and production, it is necessary to control its quality. Therefore, it is very important to find a method for the detection purity of diethylphosphonic acid CAS number 3095-95-2. There is a reliable high performance liquid chromatography method as follows: diethylphosphonic acid was diluted with 10% acetonitrile and diluted to per 1 ml solution contain 1mg-50mg diethylphosphonic acid as a test solution, and injected into a high performance liquid chromatography,Injection volume of 1-100μl, using UV detector, detection wavelength 200nm-230nm, acetonitrile-phosphate solution as the mobile phase, mobile phase flow rate of 0.5-3.0ml / min, using stationary octadecyl-bonded silica gel  to test the chromatographic purity of Diethylphosphoacetic acid CAS number 3095-95-2. The purity and content of the sample were calculated according to the peak area.

Thera. Category:Anti- cancer

Cas No.:  3095-95-2

Synonym: DIETHYLCARBOXYMETHYLPHOSPHONATE;Diethylcarboxymethylphosphonate, 98 %;(Diethoxyphosphinyl)acetic acid;2-(Diethoxyphosphinyl)acetic acid;Diethylphosphonoacetic acid,98%;DIETHYLPHOSPHONOACETIC ACID;DIETHYLPHOSPHONOETHANOIC ACID;(DIETHOXYPHOSPHINOYL)ACETIC ACID;

Molecular Formula: C6H13O5P

Molecular Weight:196.14

Assay: ≥98.%

Packing: Export worthy packing

Material Safety Data Sheet: Available on request

Usage: Intermediate of Afatinib

Related Intermediates :
1. CAS 162012-69-3, 7-Fluoro-6-nitro-4-hydroxyquinazoline
2. CAS 16499-57-3, 7-Fluoroquinazolin-4(3H)-one

         3. CAS 162012-67-1, 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro- ,

         4. 4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]- is afatinib intermediate with the    CAS number 314771-88-5, 

        5. (S)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diaMine CAS 314771-76-1

        6.  3095-95-2,Diethylcarboxymethylphosphonate