Ezetimibe Intermediate 6 CAS 204589-80-0

Basic Info

Model No.: 204589-80-0

Additional Info

Packaging: AS REQUIRED

Productivity: KGS

Brand: VOLSENCHEM

Transportation: Air

Place of Origin: CHINA

Supply Ability: TRUE MANUFACTURER

Product Description

Ezetimibe Intermediate 6 CAS number is 204589-80-0, Molecular formula C26H24FNO4, Molecular weight 433.47 ,Appearance is White crystalline powder.1-fluorobenzene and glutaric anhydride are subjected to Friedel-Crafts reaction under the action of the catalyst to give the compound 5- (4-fluorophenyl) -5-oxopentanoic acid,react with 1,3-propanediol to form the compound 4- (2- (4-fluorophenyl) -1,3-dioxan-2-yl) butanoic acid And then through four steps reaction to obtain the target product of ezetimibe intermediate 6. The difficulty in the synthesis of ezetimibe intermediate 6 is relatively big, with the fifth reaction involving low temperature reactions, which are difficult to operate for chemical plants in general terms. In addition, it is easy to produce a problem that the isomer content is too high. So the synthesis of ezetimibe intermediate 6 is definitely a test of equipment and technology.

Thera. Category: Lipid-lowering drug

Cas No.: 204589-80-0

Synonym:(intermediate of ezetimibe);(3R,4S)-1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-[4-(phenylmethoxy)phenyl]-2-azetidinone; synthesis of trans-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl-(4-benzyloxyphenyl)]-2-azetidinone;4`-O-Benzyloxy Ezetimibe

Molecular Formula:C26H24FNO4

Molecular Weight: 433.47   

Assay: ≥99.%

Packing: Export worthy packing

lMaterial Safety Data Sheet: Available on request

Usage: Synthesis Pharmaceutical Intermediates

Related intermediate:

1)(3R,4S)-4-[4-(Benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]azetidin-2-one 190595-65-4

2) 2-AZETIDINONE, 1-(4-FLUOROPHENYL)-3-[(3S)-3-(4-FLUOROPHENYL)-3-HYDROXYPROPYL]-4-[4-(PHENYLMETHOXY)PHENYL]-, (3R,4S)- cas 163222-32-0

3) Methyl (3R,4S)-1-(4-fluorophenyl)-2-oxo-4-[4-(phenylmethoxy)phenyl]-3-azetidinepropanoate cas 204589-80-0

4) N-(4- (Benzyloxy) benzylidene) -4-fluoroaniline CAS 70627-52-0 

5) Ezetimibe  163222-33-1