Organic Fluorine-containing Intermediates 4-Fluoro-3-nitrophenol CAS 2105-96-6

Basic Info

Model No.: 2105-96-6

Additional Info

Packaging: AS REQUIRED

Productivity: KGS

Brand: VOLSENCHEM

Transportation: Ocean,Air

Place of Origin: CHINA

Supply Ability: TRUE MANUFACTURER

Product Description

4-Fluoro-3-nitrophenol cas number 2105-96-6 is an important class of organic fluorine-containing intermediates, mainly used for the development of new fluorine-containing antibiotics, fluorobenzene salicylates, insecticides and liquid crystal materials. The market Demand increased year by year. Since the benzene ring of 4-fluoro-3-nitrophenol is more restricted by the nitro group and the fluorine atom which is very active in the ortho-nitro group, the conditions of raw material stability and safety are more limited, It has high synthesis difficulty. The synthetic method of the literature is using 4-fluoro-3-nitroacetophenone and organic peracid effect, oxidation rearrangement hydrolysis to get 4-fluoro-3-nitrophenol cas number 2105-96-6 . Organic peracid is expensive and dangerous because it can not be shaken. The use of peracid also produces the corresponding carboxylate waste, which does not meet the requirements of environmental economic development. In actual production, the reaction is difficult to control. The reaction Activity is poor, the yield is only 20%, basically no value of industrial development. Later, a new synthesis method was proposed. The general steps are as follows: (1) dissolving 4-fluoro-3-nitroacetophenone and H2O2 in a molar ratio of 2: 6 in an organic solvent, adding 3 times 4-fluoro-3-nitro-acetophenone amount of the catalyst, the amount of the solvent is 30-90% of the total mass of the reaction solution, the reaction temperature is 50 ℃ -80 ℃, the reaction was stirred 8-20 hours, tested by liquid chromatography to monitor Each component
(2) cooling the reaction solution obtained in the first step, centrifuging or filtering to remove the catalyst, diluting the filtrate with water;
(3) The diluted filtrate was extracted with ether and the organic layer was rotary evaporated to give the product. The preparation of the above mentioned catalysts is also very important.

Thera. Category:   Fluorine-Containing chemical

Cas No.: 2105-96-6

Synonym:4-Fluoro-3-nitrophenol;2-Fluoro-5-hydroxynitrobenzene; 3-nitro-4-fluoro phenol;4-Fluoro-3-nitorphenol;4-FLUORO-3-NITROPHENOL 98%;

Molecular Formula: C6H4FNO3

Molecular Weight:  157.1

Purity: ≥98.%

Packing:Export worthy packing

Material Safety Data Sheet:Available on request