|Min. Order:||1 Kilogram|
|Delivery Time:||25 Days|
Model No.: 443913-73-3
Grade Standard: Medicine Grade
Productivity: Custom Manufacturing
Place of Origin: CHINA
Supply Ability: In stock
Vandetanib CAS NUMBER is 443913-73-3 is a multi-target tyrosine kinase inhibitor, belongs to aniline quinazoline compounds, as known as "second generation IRESSA". It is the first approved mediastinal thyroid cancer treatment drug that is suitable for the treatment of unresectable, locally advanced or metastatic symptomatic or progressive medullary thyroid carcinoma. A randomized, placebo-controlled clinical trial showed that Vandetanib significantly delayed the progression of locally advanced or metastatic thyroid medullary carcinoma. The recommended daily dose is 300 mg and should be discontinued when the patient is resistant to the drug or can not tolerate its toxicity. According to a study published by the Journal of Clinical Oncology, Vandetanib can effectively prolong progression-free survival in patients with non-small cell lung cancer (NSCLC) compared with gefitinib, which has an inhibitory effect only on EGFR. In clinical trials if the patient progress or can not tolerate toxicity, allowing it changes the treatment program. The test results showed that the control rate of patients treated with gefitinib instead of vandetanib 443913-73-3 was 14%, compared with 32% for patients treated with vandetanib instead of gefitinib.
Vandetanib CAS 443913-73-3, also called ZD647, Zactima, Caprelsa and CH 331, is an important product in our company. Vandetanib CAS NO 443913-73-3 appearance crystalline solid is a broad spectrum, orally available, small molecule and multi target tyrosine kinase inhibitor including vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR). Vandetanib 443913-73-3 is soluble in methanol, DMSO (4 mg/ml at 25℃), water (<1 mg/ml at 25℃), and ethanol (<1 mg/ml at 25℃). We have large quantity in stock. And if you need ZD647, please contact us. We can offer best service and bottom price.
Thera Category: VEGFR2 Inhibitor
Cas No.: 443913-73-3
Synonym: VANDETANIB;4-Quinazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-;Vandetanib for research;4-(4-Bromo-2-fluoroanilino)-6-methoxy- 7-[(1-methylpiperidin-4-yl)methoxy]quinazoline;N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine;Zactima;ZD 6474;7-((4-aminocyclohexyl)methoxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine
Molecular Weight: 475.35
Specifications: Available on request
Packing:Export worthy packing
Material Safety Data Sheet:Available on request