Potent VEGFR2 Inhibitor of Vandetanib CAS 443913-73-3

Payment Type: L/C,T/T
Incoterm: FOB,CIF
Min. Order: 1 Kilogram
Delivery Time: 25 Days

Basic Info

Model No.: 443913-73-3

Grade Standard: Medicine Grade

State: Solid

Additional Info

Packaging: 25KGS/DRUM

Productivity: Custom Manufacturing


Transportation: Air

Place of Origin: CHINA

Supply Ability: In stock

Product Description

Vandetanib CAS NUMBER is 443913-73-3 is a multi-target tyrosine kinase inhibitor, belongs to aniline quinazoline compounds, as known as "second generation IRESSA". It is the first approved mediastinal thyroid cancer treatment drug that is suitable for the treatment of unresectable, locally advanced or metastatic symptomatic or progressive medullary thyroid carcinoma. A randomized, placebo-controlled clinical trial showed that Vandetanib significantly delayed the progression of locally advanced or metastatic thyroid medullary carcinoma. The recommended daily dose is 300 mg and should be discontinued when the patient is resistant to the drug or can not tolerate its toxicity. According to a study published by the Journal of Clinical Oncology, Vandetanib can effectively prolong progression-free survival in patients with non-small cell lung cancer (NSCLC) compared with gefitinib, which has an inhibitory effect only on EGFR. In clinical trials if the patient progress or can not tolerate toxicity, allowing it changes the treatment program. The test results showed that the control rate of patients treated with gefitinib instead of vandetanib 443913-73-3 was 14%, compared with 32% for patients treated with vandetanib instead of gefitinib. 

Vandetanib CAS 443913-73-3, also called ZD647, Zactima, Caprelsa and CH 331, is an important product in our company. Vandetanib CAS NO 443913-73-3 appearance crystalline solid is a broad spectrum, orally available, small molecule and multi target tyrosine kinase inhibitor including vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR). Vandetanib 443913-73-3 is soluble in methanol, DMSO (4 mg/ml at 25℃), water (<1 mg/ml at 25℃), and ethanol (<1 mg/ml at 25℃). We have large quantity in stock. And if you need ZD647, please contact us. We can offer best service and bottom price.       

Thera Category: VEGFR2 Inhibitor

Cas No.:  443913-73-3

Synonym: VANDETANIB;4-Quinazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-;Vandetanib for research;4-(4-Bromo-2-fluoroanilino)-6-methoxy- 7-[(1-methylpiperidin-4-yl)methoxy]quinazoline;N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-4-quinazolinamine;Zactima;ZD 6474;7-((4-aminocyclohexyl)methoxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine


Molecular Formula:C22H24BrFN4O2

Molecular Weight: 475.35

Specifications: Available on request

Packing:Export worthy packing

Material Safety Data Sheet:Available on request

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