Pyridine-3-Sulfonyl Chloride Used For Vonoprazan 16133-25-8

Basic Info

Model No.: 16133-25-8

Function: Nutritional Therapeutics

Grade Standard: Medicine Grade

State: Solid

Volatile: Not Volatile

Additional Info

Packaging: AS REQUIRED

Productivity: KGS

Brand: VOLSENCHEM

Transportation: Air

Place of Origin: CHINA

Supply Ability: TRUE MANUFACTURER

Certificate: ISO

Product Description

 Vonoprazan fumarate intermediate Pyridine-3-sulfonyl chloride CAS number is 16133-25-8, It is a commonly used pharmaceutical intermediate, the appearance of a colorless transparent liquid, very unstable in water, easy to hydrolyze to formPyridine-3-sulfonyl chloride and hydrochloric acid lose their reactivity. The existing detection methods are mainly carried out by adding a derivatization reagent to pyridine-3-sulfonyl chloride and then detecting by gas chromatography, or by direct injection using gas chromatography, or directly by nuclear magnetic resonance spectroscopy. The disadvantages of gas chromatography detection are as follows: 1. The degree of derivatization is not well controlled; 2. Pyridine-3-sulfonyl acid can also react with derivatization reagents, and like pyridine-3-sulfonyl chloride derivatization products, it will interfere the accuracy of the detection; 3, due to the strong corrosive nature of pyridine-3-sulfonyl chloride, the direct injection method will cause corrosion to the column and instrument pipeline, and the reproducibility is poor. In summary, the accuracy, specificity and reproducibility of gas chromatography are not good. The main drawbacks of NMR spectroscopy detection are: pyridine-3-sulfonyl acid interferes with detection, making the specificity and accuracy poor. Moreover, the requirements for the NMR spectrometer are high and are not suitable for practical applications.
There is a reasonable method for detecting the content of pyridine-3-sulfonyl chloride. The determination conditions of the method include: (1), weighing the sample, adding an organic solvent to dissolve, and preparing a sample stock solution; (2) measuring the sample stock solution Add alkaline solution, dilute with water, add nitric acid solution, use potentiometric titration with first titration solution, calculate total chlorine; (3), take sample stock solution, dilute with water, add nitric acid solution, use second titration The liquid was subjected to potentiometric titration to calculate the amount of free acid; (4) The content of pyridine-3-sulfonyl chloride in the sample was calculated. This method can accurately determine the content of pyridine-3-sulfonyl chloride in the sample. The detection method has strong specificity, high precision, high accuracy and convenient operation, and can effectively control the quality of Pyridine-3-sulfonyl chloride CAS number 16133-25-8

Thera. Category:Anti-gastric

Cas No.: 16133-25-8

Synonym:Vonoprazan-029;Vonoprazan Fumarate impurity P;3-CHLOROSULFONYL-PYRIDINIUM, CHLORIDE;3-PYRIDINESULFONYL CHLORIDE, HCL;3-CHLOROSULFONYL-PYRIDINIUM;TAK438 Impurity 68;3-PYRIDINESULFONYL CHLORIDE HYDROCHLORIDE;PYRIDINE-3-SULFONYL CHLORIDE HYDROCHLORIDE

Molecular Weight: 177.61

Molecular formula:C5H4ClNO2S

Assay: ≥98.%

Appearance: White Crystalline solid

Packing:Export worthy packing

Material Safety Data Sheet:Available on request

Related intermediate: 

1) 5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde CAS number 881674-56-2

2) 1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1-(3-pyridinylsulfonyl)- CAS number is 881677-11-8

3) Vonoprazan Fumarate (TAK-438) Cas 881681-00-1