Model No.: 85700-55-6
Scopine hydrochloride CAS number is 85700-55-6, which is the main starting material for the synthesis of Tiotropium Bromide intermediate,Scopine Di(2-thienyl) Glycolate , the main operation process is as follows: 10 g of tocopherol hydrochloride, 26 g of aluminum trichloride-diatomaceous earth catalyst and 50 ml of a cyclohexane/acetonitrile mixed solvent (volume ratio of cyclohexane to acetonitrile of 10:1) were added to a 100 mL flask, and nitrogen gas was passed through at room temperature. After stirring for 30 minutes, 16.4 g of methyl 2,2-bis(2-thienyl)glycolate was further added, followed by heating to 65 to 70℃, and stirring, and the reaction was terminated after 8 hours. The reaction solution was diluted with 200 mL of dichloromethane, and the insoluble material was removed by filtration. The filtrate was washed twice with water and then washed with brine. The residue was dried over anhydrous sodium Add acetonitrile to dissolve the residue, add activated carbon at room temperature, heat to reflux for half an hour, then filter while hot, concentrate the filtrate under reduced pressure to 1/4 volume, stop concentration, stir at room temperature for 5 hours, filter, filter cake with a small amount After washing with acetonitrile, it was air-dried at room temperature to give a crude white solid, 2,2-bis(2-thienyl)glycolate. The obtained crude product was purified by acetonitrile to give a fine product.
To a large extent, the quality and cost of Scopine hydrochloride CAS number 85700-55-6 determines the quality and cost of tiotropium bromide, so many companies that do tiotropium have focused their efforts on the development and improvement of Scopine hydrochloride CAS 85700-55-6,.
Thera. Category: Bronchodilator
Cas No.: 85700-55-6
Synonym:SCOPINE HCL;SCOPINE HYDROCHLORIDE;Scopine Hel;(1α,2β,4β,5α,7β)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02.4]nonan-7-ol hydrochloride;Scopine Hel or scopine hydrochloride;(1α,2β,4β,5α,7β)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-ol,hydrochloride (1:1);East tropic alcohol hydrochloride
Packing: Export worthy packing
lMaterial Safety Data Sheet: Available on request