Senior Intermediate of Lubiprostone 136790-77-7

Unit Price: USD 1.0000 / Kilogram
Payment Type: T/T
Incoterm: CIF
Min. Order: 1 Kilogram
Delivery Time: 15 Days

Basic Info

Model No.: 136790-77-7

Additional Info

Packaging: AS REQUIRED

Productivity: KGS


Transportation: Air

Place of Origin: CHINA


Product Description

Lubiprostone Heptanoate CAS number is 136790-77-7 which is a senior intermediate of Lubiprostone, the synthesis is very difficult. There are three ways to synthesize Lubiprostone Heptanoate, the first is to use p-phenylbenzoylcolicide as raw material, synthesize the fluorine-containing  lower side chain and then synthesize the carboxyl group-containing upper side chain The used reagent is methyl ester. The second is based on the coriolide protection base as the starting material, let its hydroxyl was protected by Dihydropyran, the use of the upper side chain is acid, and the lower side chain does not protect the hydroxyl group. The above step of two ways are longer and the upper side of the chain is expensive, and use the toxic reagents ethanol thallium. The third is based on (-) coriolide as raw material, dissolved in DMF, followed by adding imidazole and DMF solution containing tert-butyl dimethyl chlorosilane, through the reaction to selectively protect the primary hydroxyl. This idea owns low price of starting material, low toxicity of the use of reagents,good, safety, the reaction step is shorter than the before two ideas.

Thera. CategoryConstipation Treatment

Cas No.136790-77-7 

Synonym:intermediate of Lubiprostone; Benzyl (Z)-7-[(1R,2R,3R,5S)-2-(4,4-difluoro-3-hydroxyoctyl)-5-hydroxy-3-[(tetrahydro-2H-pyran-2-yl)oxy]cyclopentyl]hept-5-enoate;16,16-difluoro-9,15-dihydroxy-11-[(tetrahydro-2H-pyran-2-yl)ox


Molecular Formula:C32H48F2O6

Molecular Weight: 566.7167264


PackingExport worthy packing

lMaterial Safety Data SheetAvailable on request

Usage:Lubiprostone can treat constipation. It can also treat irritable bowel syndrome (IBS) with constipation in women

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