Urinary System Drug Propiverine Hydrochloride Intermediate CAS 3608-67-1

Unit Price: USD 1.0000 / Kilogram
Payment Type: T/T
Incoterm: FOB
Min. Order: 1 Kilogram
Delivery Time: 1 Days

Basic Info

Model No.: 3608-67-1

Additional Info

Packaging: AS REQUIRED

Productivity: 2T/M


Transportation: Ocean,Air

Place of Origin: CHINA


Certificate: ISO

Product Description

Propiverine Hydrochloride Intermediate Enpiperate has the chemical name of 1-methyl-4-piperidyl diphenylglycolate CAS 3608-67-1, the appearance of a white to off-white solid, it can be obtained through diphenylglycolic acid form salt in alkaline solution with 1-methyl-4-halogenated piperidine reaction. The specific process is as follows: add 65gram diphenylglycolic acid into three-necked flask with 200ml of toluene,stirring and at same time dropwise with 5% NaoH solution to neutralize and evaporated to remove the water containing toluene, extra added toluene to a volume of 200ml, add 38g 1-methyl - 4-Chloropiperidine, stirred at a temperature of 50-150 ℃, the reaction was refluxed for 161 hours, cooled to room temperature, precipitated a large amount of light yellow crystals, suction filtration, washed with water, dried to give a white to pale white solid 74g, it is called Enpiperate cas number 3608-67-1. After a simple calculation of the total yield of this route is 80%. The HPLC test results was 97.5%.

l Thera. Category:Diabetes Insipidus Treatment

l Cas No.: 3608-67-1

l Synonym: Hydroxy-diphenyl-acetic acid 1-Methyl-piperidin-4-yl ester;1-Methylpiperidin-4-yl 2-hydroxy-2,2-diphenylacetate;1-methyl-4-piperidyl diphenylglycolate;enpiperate;2-Hydroxy-2,2-diphenylacetic acid 1-methyl-4-piperidinyl ester;Hydroxydiphenylacetic acid 1-methyl-4-piperidyl ester;N-Methyl-4-piperidyl benzilate;α-Hydroxy-α-phenylbenzeneacetic acid 1-methyl-4-piperidinyl ester;

l Molecular Formula:C20H23NO3


l Molecular Weight: 325.40152

l Assay: ≥98.%

l Packing:Export worthy packing

l Material Safety Data Sheet:Available on request

l Usage: Intermediate of Propiverine Hydrochloride

Chemical name Specification Color batch quantity
3608-67-1 α-hydroxy-α-phenyl-Benzeneacetic acid, 1-methyl-4-piperidinyl ester HPLC 95%(included next target material98%) White to offer solid 100
54556-99-9 α-chloro-α-phenyl-Benzeneacetic acid, 1-methyl-4-piperidinyl ester, hydrochloride HPLC 98.0% dark brown solid 100
60569-19-9 α-phenyl-α-propoxy-Benzeneacetic acid, 1-methyl-4-piperidinyl ester
HPLC 99.0% white solid 100
54556-98-8 α-phenyl-α-propoxy-Benzeneacetic acid, 1-methyl-4-piperidinyl ester, hydrochloride (1:1)
Propiverine hydrochloride
HPLC 99.5% white solid 100

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