1-(4-Fluorobenzyl)-2-chlorobenzimidazole For Mizolastine

Payment Type: L/C,T/T
Incoterm: FOB
Min. Order: 1 Kilogram
Delivery Time: 15 Days

Basic Info

Model No.: 84946-20-3

Additional Info

Packaging: AS REQUIRED

Productivity: KGS

Brand: VOLSENCHEM

Transportation: Air

Place of Origin: CHINA

Supply Ability: TRUE MANUFACTURER

Certificate: ISO

Product Description

Mizolastine intermediate 4 CAS number is 84946-20-3, full chemical name of 1-(4-Fluorobenzyl)-2-chlorobenzimidazole, it is the key intermediate for the preparation of mizolastine, there are two traditional synthetic routes.Firstly,use o-phenylenediamine as raw material, adding dilute hydrochloric acid to react to get o-benzene Diammonium monohydrochloride, then mixed with urea, fused and condensed at high temperature to obtain 2-hydroxybenzimidazole, and then add 4-fluorobenzyl chloride to process N-dealkylation, obtain 1- (4-fluorobenzyl) -1 , 3-dihydro-2H-benzimidazol-2-one, and then use chlorinated phosphorus oxychloride to give the desired product. Second, the process from the starting material to the second step, 2-hydroxybenzimidazole, is exactly the same as the first route, except that this route, after obtaining 2-hydroxybenzimidazole, Phosphorus reaction to give 2-chlorobenzimidazole, N-alkylation with 4-fluorobenzyl chloride to give the target compound Mizolastine Intermediate 4 CAS number 84946-20-3..

Thera. Category:anti-histamine and anti-allergic 

Cas No.: 84946-20-3

Synonym: lndobufen;INDOBNFEN;2-[4-(1-oxo-2-isoindolinyl)phenyl]butyric acid

84946-20-3

Molecular Weight:  260.69

Molecular formula:C14H10ClFN2

Assay: ≥98.%

Appearance: White Crystalline solid

Packing:Export worthy packing

Material Safety Data Sheet:Available on request

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