1-Bromo-3,5-Dimethyladamantane Used for Memantine CAS 941-37-7

Unit Price: USD 1.0000 / Kilogram
Incoterm: CIF
Min. Order: 1 Kilogram
Delivery Time: 15 Days

Basic Info

Model No.: 941-37-7

Additional Info

Packaging: As required

Productivity: Commercial


Transportation: Air

Place of Origin: CHINA

Certificate: Technical Support

Product Description

1-Bromo-3,5-dimethyladamantane is intermediate 2 of Memantine hydrochloride, CAS number is 941-37-7, usually it is brominated from 1,3-dimethyladamantane. Researchers adjusted conventional synthetic methods through experiment. The specific experimental operation is as following, take 200gram 1,3 - dimethyladamantane, placed in three bottles, then connect drying tube and exhaust gas absorption device. Heated to 75 ° C,  drop 190 ml of bromine, reacted for 26 hours, and cooled to room temperature. Add 400ml methylene chloride,cooling by ice bath, add saturated sodium bisulfite solution to the mixture into a pale yellow solution. Static stratification, divided organic phase. The aqueous phase was extracted with methylene chloride and combined organic phases, washed with saturated sodium carbonate solution till neutral,then washed with saturated sodium chloride solution. Then the organic phase was dried over anhydrous sodium sulfate, concentrated under reduced pressure and the fraction was collected at 80 ° C to get 275gram colorless transparent liquid, the yield is more than 92%. His preparation process is relatively simple, and then further synthesis of the preparation of its next step is the most difficult on process of the memantine hcl. The conventional practice is take reaction metamorphine hydrochloride intermediate 2 with nitriles and concentrated sulfuric acid, but the resulting mixture is very viscous and it is very difficult to stir at the post-reaction stage, resulting in a low yield. We believe that this method should be adjusted to take reaction the memantine hydrochloride 2 CAS number 941-37-7 and nitrile, concentrated sulfuric acid and organic acid , after the end of the reaction,pour into the water. This method not only solves the problem of agitation difficult, but also greatly simplifies the post-reaction operation.

Thera. Category:  Parkinsonism Alzheimers Disease Treatment 

Cas No.:941-37-7

Synonyms: 1-BROMO-3,5- DIMETHYL DAMANTANE;1,3-Dimethyl-5-bromoadamantane;tricyclo[,7~]decane, 1-bromo-3,5-dimethyl-;NSC 102293;1-Bromo-3,5-dimethyltricyclo[,7]decane;1-BROMO-3,5-DIMETHYLADAMANTANE;3,5-dimethyl-1-bromo- adamantane;1-Bromo-3,5-Dimethyl;

NW: 243.18

M.W.: C12H19Br


Assay: ≥99%

Packing:Export worthy packing

Material Safety Data Sheet:Available on request

Usage: Intermediate of  Memantine

1)1,3-dimethyladamantane CAS number 702-79-4

2) 1-Bromo-3,5-dimethyladamantane  CAS number  941-37-7

Active Pharmaceutical Ingredients> Cas 90098-04-7,Rebamipide Named In Mucosta With GMP Standard
Active Pharmaceutical Ingredients> Functional Dyspepsia Treatment Acotiamide Hydrochloride Trihydrate CAS 773092-05-0
Active Pharmaceutical Ingredients> Acotiamide Hydrochloride For Gastric Motility Improvement CAS 185104-11-4
Contract Manufacturing> ASCORBYL GLUCOSIDE Used for Comesitc Additive CAS 129499-78-1
Pharmaceutical Intermediates> Anti-Ulcerative> 2-Aminothiazole-4-ethylformate For Making Acotiamide Cas 5398-36-7
Pharmaceutical Intermediates> Anti-Ulcerative> Acotiamide INT CAS NUMBER 185105-98-0
Pharmaceutical Intermediates> Anti-Cardiovascular> Azilsartan Used for Hypertension Treatment CAS 147403-03-0
Pharmaceutical Intermediates> Anti-Diabetes> Sitagliptin Phosphate Monohydrate Treated for Type 2 diabetes CAS Number 654671-77-9
Pharmaceutical Intermediates> Anti-Ulcerative> Cas 132210-24-3, 2-Amino-3-(1,2-dihydro-2-oxo-quinoline-4-yl)Propanoic acid Hydrochloride For Rebamipide
Pharmaceutical Intermediates> Anti-Ulcerative> Cas 1068-90-2 White Crystalline Powder Diethyl Acetamidomalonate For Rebamipide(DAAM)
Active Pharmaceutical Ingredients> 6027-23-2, Hordenine HCL Powder
Pharmaceutical Intermediates> Anti-Ulcerative> Cas 4876-10-2,4-Bromomethyl-2(1H)-quinolinone (BMQ) For Rebamipide/ Mucosta
Pharmaceutical Intermediates> Anti-Respiratory> CAS 2338-18-3, 2-Aminoindan hydrochloride For Making Indacaterol
Pharmaceutical Intermediates> Anti-Respiratory> CAS 312753-53-0/ 5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride Used for Indacaterol
Pharmaceutical Intermediates> Anti-Respiratory> 312753-53-0, Indacaterol Intermediate
Pharmaceutical Intermediates> Anti-Respiratory> 100331-89-3, Indacaterol Intermediate

© 2019 CHINA WAY. All Rights Reserved.  Taizhou Volsen Chemical Co., Ltd.,  Inc.   All rights reserved. site map.  sitemap.html