|Unit Price:||USD 1.0000 / Kilogram |
|Min. Order:||1 Kilogram|
|Delivery Time:||15 Days|
Model No.: 52099-72-6
Packaging: As required
Place of Origin: CHINA
Certificate: Technical Support
Flibanserin intermediate named 1,3-Dihydro-1-(1-methylethenyl)-2H-benzimidazole-2-one CAS number is 52099-72-6, molecular formula of C10H10N2O, molecular weight of 174.2. The related literature describes his synthesis process, starting with benzoylacetate and ring-closing reaction with o-phenylenediamine to obtain the target compound 1,3-Dihydro-1-(1-methylethenyl)-2H-benzimidazole-2-one CAS number 52099-72-6. The disadvantage of this method is that the high boiling point of benzoylacetate requires limited control of the substance and the acetophenone produced by the deprotection of the acid treatment in the next step, thereby increasing the difficulty of quality control.
There are two ways to synthesize 1,3-dihydro-1-(1-methylethynyl)-2H-benzimidazol-2-one, one is worthy of reference, one is o-diphenylamine, ethyl acetoacetate, 1,2-dibromoethane, piperazine and m-bromobenzotrifluoride are used as raw materials, and the target product is obtained by a ring-closing reaction. The specific process is: adding 1L of ethanol to the reaction flask, adding 150g of o-diphenylamine, adding 300g of potassium hydroxide, then adding 172g of ethyl acetoacetate dropwise, stirring at room temperature, and controlling the reaction; after the reaction is finished, the reaction liquid is concentrated. The reaction solution was added to water, filtered, washed with water, and dried to obtain 241 g of 1,3-dihydro-1-(1-methylethynyl)-2H-benzimidazol-2-one in a yield of 91%;
Secondly, 10 g of 1-isopropenyl-2-benzimidazolone was added to 50 mL of DMF, cooled to 10℃ in an ice bath, and the temperature was controlled below 20℃. 4 g of potassium carbonate was slowly added, and the mixture was stirred at room temperature for 1 hour. After the dropwise addition, 14.2 g of 2-bromoethanol was added dropwise, and the mixture was stirred at room temperature for 8 hours. The reaction mixture was poured into ice water and extracted with dichloromethane. The extract was washed with water, dried, and evaporated to dryness (1-Methylethynyl)-2H-benzimidazol-2-one, yield is 80%.
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Synonyms:1-lsopropenyl-2-benziMidazolidinone;3-Isopropenyl-1H-benzimidazole-2(3H)-one;1-(prop-1-en-2-yl)-1H-benzo(d)imidazol-2(3H)-one;1-Isopropyl-2-benzimidazolidinone,99%;N-Isopropenyl-2-benzimidazolone;1-Isopropyl-2-benzimidazolidinone, 99%;2H-BenziMidazol-2-one, 1,3-dihydro-1-(1-Methylethenyl)-;1-(2-Propenyl)-1,3-dihydro-benziMidazol-2H-one;
Packing:Export worthy packing
Material Safety Data Sheet:Available on request