(1R,3S)-3-Aminocyclopentanol hydrochloride CAS number 1279032-31-3

Basic Info

Model No.: 1279032-31-3

Additional Info

Packaging: As required

Productivity: 10KG/M

Brand: VOLSENCHEM

Transportation: Air

Place of Origin: CHINA

Certificate: Technical Support

Product Description

(1R,3S)-3-Aminocyclopentanol hydrochloride CAS number is 1279032-31-3, which is a key starting material for Bictegravir. Some literatures have reported on his synthesis process, first using tert-butyl (1S, 3R)-3-acetylcyclopentylcarbamate as raw material, oxidizing with m-chloroperoxybenzoic acid, then hydrolyzing, and finally deprotecting with hydrogen chloride to get ( 1R,3S)-3-Aminocyclopentanol hydrochloride, the m-chloroperoxybenzoic acid used in the method is a strong oxidant, which is easily decomposed by thermal decomposition; at the same time, m-chloroperoxybenzoic acid usually contains certain Moisture not only affects the yield of the oxidation reaction, but also increases the formation of impurities, and the by-product chlorobenzoic acid, which is a by-product of the reaction, also increases the handling difficulty; and the m-chloroperoxybenzoic acid is expensive, resulting in high production cost. At the same time, the hydrogen chloride gas used in the method is a toxic gas with a pungent odor, which has a strong stimulating effect on the eye and respiratory mucosa, and has a high risk factor and high operational requirements in industrial applications. Moreover, the deprotection reaction is carried out using hydrogen chloride gas, and the process stability is poor. The process of (1R,3S)-3-aminocyclopentanol hydrochloride CAS number  1279032-31-3 also requires intensive research to achieve the desired effect.

Thera. Category:Integrase Inhibitor 

Cas No.:1279032-31-3

Synonyms:Intermediate of Bictegravir;(1R,3S)-3-aminocyclopentanolHCL;1R,3S)-3-Aminocyclopentanol hydrochloride(Bictegravir)

MF:C5H12ClNO

NW:137.60788

Assay: ≥99%

Packing:Export worthy packing

Material Safety Data Sheet:Available on request

Usage: Intermediate of  Bictegravir