2,3-DIMETHYL-6-NITRO-2H-INDAZOLECAS For Pazopanib 444731-73-1

Unit Price: USD 1.0000 / Kilogram
Incoterm: FOB
Min. Order: 1 Kilogram
Delivery Time: 7 Days

Basic Info

Model No.: 444731-73-1

Additional Info

Packaging: 1KGS/DRUM

Productivity: Commercial scale


Place of Origin: CHINA

Product Description

Pazopanib Hydrochloride Intermediate 2,3-DIMETHYL-6-NITRO-2H-INDAZOLECAS as known as Pazopanib nitro indazole CAS number is 444731-73-1. Many synthetic pathways have been reported for the synthesis of pazopanib hydrochloride with pazopanil nitro indazole as the starting material, and the final drug is prepared by reduction, coupling, methylation and coupling in four steps. As a key starting material, the quality of pazopanib nitroindazol directly determines the yield of the entire synthetic route and the quality of the final product, so its effective synthesis method is also particularly critical. Most people with o-ethyl aniline as raw materials, through nitrification, nitro cyclization and methylation and other multi-step reaction to get pazopanib nitroindazole, this route is no outstanding bright spot, we think it is not the best route. There is a better synthetic route, use o-nitroethylbenzene as raw materials, through the halogenated, nitro reduction, diazo ring and methylation and other multi-step reaction to get the target product. This route has two advantages, first,purity is high. A small amount of mono- or poly-substituted isomeric by-products can be removed by recrystallization. Second, the reaction process does not use precious metal catalyst, the cost is low.

Thera. Category: Anti -cancer

Cas No.: 444731-73-1

Synonym:2,3-dimethyl-6-nitro-1H-indazole;2,3-Dimethyl-6-nitro-1H-i...;2H-Indazole, 2,3-diMethyl-6-nitro-;3-Methly-6-nitroindazole;2,3-DIMETHYL-6-NITRO-2H-INDAZOLE;

Molecular Formula:C9H11N3


Molecular Weight:161.2

Pharmacopeia: In house Spec.

Specifications:Available on request

Packing:Export worthy packing

Material Safety Data Sheet:Available on request

Pazopanib Intermediate lists:

2,3-Dimethyl-2H-indazol-6-amine, CAS  444731-72-0

2,3-DIMETHYL-6-NITRO-2H-INDAZOLE,CAS 444731-73-1   

3-methyl-6-nitro-2H-indazole CAS number  1313372-75-6

2-Ethyl-5-nitrobenzenamine, CAS numbe  20191-74-6.

2-Methyl-5-AMiobenzenesulfonmide CAS 6973-09-7,

2-methyl-5-nitrobenzenesulfonamide  CAS number 6269-91-6,

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