2-Chloro-4-Fluoro-5-Nitrotoluene Used for Ceritinib CAS 112108-73-3

Unit Price: USD 1.0000 / Kilogram
Incoterm: FOB
Min. Order: 1 Kilogram
Delivery Time: 7 Days

Basic Info

Model No.: 112108-73-3

Additional Info

Packaging: 1KGS/DRUM

Productivity: Commercial scale


Place of Origin: CHINA

Product Description

Ceritinib intermediate as known as 2-chloro-4-fluoro-5-nitrotoluene CAS number is 112108-73-3, Molecular formula is C7H5ClFNO2, Molecular weight is189.57. If use 2-chloro-4-fluorotoluene as a raw material, only 1 step reaction can be obtained, so it was also called the first step intermediate, This step is not complicated, the general experimental operation is as follows: put 135ML concentrated sulfuric acid into the reaction bottle, stirring in the ice bath, dropping 43.4 grams of fuming nitric acid. After dripping, continue to stir for half an hour to form mixed acid. While at the same time, put 315ML concentrated sulfuric acid and 90 grams of 2-chloro-4-fluorotoluene into another three bottles.The mixed acid of nitric acid and sulfuric acid was added to the sulfuric acid solution of 2-chloro-4-fluorotoluene under cooling with ice-salt bath for 1 to 2 hours. The reaction solution was slowly added to the crushed ice and stirred, and the ethyl acetate was extracted twice. Ethyl acetate was combined, washed twice with water and once with saturated brine. The organic phase was concentrated to dryness to give the oil object product 2-chloro-4-fluoro-5-nitrotoluene CAS number 112108-73-3.

Thera. Category: Anti -cancer

Cas No.: 6269-91-6

Synonym4-Chloro-2-fluoro-5-methylnitrobenzene, 1-Chloro-5-fluoro-2-methyl-4-nitrobenzene;1-CHLORO-5-FLUORO-2-METHYL-4-NITRO-BENZENE;2-Chloro-4-fluoro-5-nitrotoluene;Benzene, 1-chloro-5-fluoro-2-Methyl-4-nitro-;

Molecular FormulaC7H5ClFNO2


Molecular Weight: 189.57

Pharmacopeia: In house Spec.

Specifications:Available on request

Packing:Export worthy packing

Material Safety Data Sheet:Available on request

Related Intermediates : 

CAS 1032903-50-6,1-Chloro-5-isopropoxy-2-methyl-4-nitrobenzene 

CAS 76697-50-2,1-Amino-2-(isopropylsulphonyl)benzene

CAS 761440-16-8, 2,5-Dichloro-N-(2-(isopropylsulfonyl)-phenyl)pyrimidin-4-amine

2-chloro-4-fluoro-5-nitrotoluene CAS number 112108-73-3

[2-(isopropylthio)phenyl]amine hydrochloride CAS number  861343-73-9

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