[2-(isopropylthio)phenyl]amine Hydrochloride For Making Ceritinib CAS 861343-73-9

Unit Price: USD 1.0000 / Kilogram
Incoterm: FOB
Min. Order: 1 Kilogram
Delivery Time: 7 Days

Basic Info

Model No.: 861343-73-9

Additional Info

Packaging: 1KGS/DRUM

Productivity: Commercial scale


Place of Origin: CHINA

Product Description

Ceritinib intermediate called [2-(isopropylthio)phenyl]amine hydrochloride CAS number is 861343-73-9, Its synthesis method is relatively simple, the steps are shorter, only use 2-bromopropane and 2-mercapto aniline as raw material,through one step reaction to get [2-(isopropylthio)phenyl]amine hydrochloride CAS 861343-73-9, but it is noted that the molar ratio of the two materials is 1.0 to 1.3: 1, preferably 1: 1, the reaction time is 2 to 24 hours, preferably 3-5 hours. The reaction solvent is isopropanol. There is a method may be more reasonable, Use1-fluoro-2-nitrobenzene and isopropyl mercaptan as raw materials, adding DMF and K2CO3 to get the first step material 2-fluoroaniline, palladium carbon as a catalyst for catalytic hydrogenation, The product is [2-(isopropylthio)phenyl]amine and then the form salt to obtain the desired product of  2-(isopropylthio)phenyl]amine hydrochloride CAS 861343-73-9.

Thera. Category: Anti -cancer

Cas No.: 861343-73-9

Synonym:BenzenaMine, 2-[(1-Methylethyl)thio]-, hydrochloride;[2-(isopropylthio)phenyl]amine hydrochloride;BenzenaMine, 2-[(1-Methylethyl)thio]-, hydrochloride (1:1);

Molecular FormulaC9H14ClNS

CAS 861343-73-9

Molecular Weight: 203.732

Pharmacopeia: In house Spec.

Specifications:Available on request

Packing:Export worthy packing

Material Safety Data Sheet:Available on request

Related Intermediates : 

CAS 1032903-50-6,1-Chloro-5-isopropoxy-2-methyl-4-nitrobenzene 

CAS 76697-50-2,1-Amino-2-(isopropylsulphonyl)benzene

CAS 761440-16-8, 2,5-Dichloro-N-(2-(isopropylsulfonyl)-phenyl)pyrimidin-4-amine

2-chloro-4-fluoro-5-nitrotoluene CAS number 112108-73-3

[2-(isopropylthio)phenyl]amine hydrochloride CAS number  861343-73-9

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