2-Chloroisonicotinic Acid For Making Lafutifine Cas Number 6313-54-8

Basic Info

Model No.: 6313-54-8

Additional Info

Packaging: 25KGS/DRUM

Productivity: 100T/Y

Brand: VOLSENCHEM

Place of Origin: CHINA

Product Description

Lafutidine intermediate named as 2-Chloroisonicotinic acid cas number 6313-54-8, Molecular formula: C6H4ClNO2, Appearance is white or almost white solid, which is a typical pyridine series. We often use citric acid as raw material, through chlorination reaction to get 2,6-dichloroisonicotinic acid, and then through directional dechlorination reaction to get 2-chloroisonicotinic acid cas number 6313-54-8. it not only used to synthesize lafutifine,but also used to synthesize Topiroxostat and other commonly pharmaceutical intermediates. We have done a lot of same type with 2-chloroisonicotinic acid or use it as the starting material of the product, we make research more on its properties and application. For example: use 2-chloroisonicotinic acid as raw material, under the condition of sulfoxide and take esterification with small molecular alcohol to get 2-chloroisonicotinate, It was reduced to 2 - chloropyridine - 4 - methanol by reducing agent and finally 2-chloropyridine-4-methanol and aqueous ammonia were subjected to amination reaction under the catalysis of copper catalyst to obtain 2-aminopyridine-4-methanol. Another example, use 2-chloro isonicotinic acid as the starting material, potassium ferrocyanide as green cyanide, AgI-KI-PEG as a hybrid catalytic system, firstly cyanidation to produce 2-cyanoisonicotinic acid, and then directly use Phenyl Dichlorophosphat(PDCP) as the amide condensation agent under the action of hydrazine hydrate to get 2-cyanoisonic nicotinic acid hydrazide, and then condensate with 4-cyanopyridine to get Topiroxostat

Thera. Category:Antiulcerative 

Cas No.:6313-54-8

Synonym:2-CHLOROPYRIDINE-4-CARBOXYLIC ACID;2-Chloroisonicotinic;RARECHEM AL BO 0840;TIMTEC-BB SBB004003;BUTTPARK 43\57-03;2-CHLORO-4-PYRIDINYL CARBOXYLIC ACID;2-CHLORO-4-PYRIDINECARBOXYLIC ACID;2-CHLOROISONICOTINIC ACID;

Molecular Formula:C6H4ClNO2

Molecular Weight:157.55

Pharmacopeia: In house Spec.

Specifications:Available on request

Packing:Export worthy packing

Material Safety Data Sheet:Available on request

Usage :Intermediates for Lafutifine

Competitive Advantage: Good quality and favorable price

Related intermediate of Lafutidine

1) 4-Nitrophenyl 2-(furfurylsulfinyl)acetic acid CAS 123855-55-0)

2) N-{4-[4-(Piperidinomethyl)pyridyl-2-oxy]-cis-2-butene}phthalimide maleic acid CAS 146447-26-9

3)  2-Chloroisonicotinic acid CAS 6313-54-8