406484-56-8,2-Chloro-4-(1-piperidinylmethyl)pyridine Ethanedioate for Lafutidine

Incoterm: CIF
Min. Order: 1 Kilogram
Delivery Time: 7 Days

Basic Info

Model No.: 406484-56-8

Additional Info

Packaging: 25KGS/DRUM

Productivity: 100T/Y

Brand: VOLSENCHEM

Place of Origin: CHINA

Product Description

Lafutidine pyridine ethanedioate CAS number is 406484-56-8, through in-depth study of the synthetic route of lafutidine and we found that lafutidine pyridine ethanedioate is the key raw material for the synthesis of lafutidine. How to obtain this intermediate through a simple step,which determined the synthetic cost of synthetic lafutidine. One method is more reliable, the specific method is as follows: (1) in the ice salt bath under freezing conditions, Dropping nitrite aqueous solution in acid and 2-amino-4-methyl pyridine for reaction, and then raising the temperature to 70-100 DEG C, after 15-30 minutes, cooling, adjusting PH value 6.0-8.0, heating to 60 DEG C, extracting the hot reaction solution with ethyl acetate, recrystallizing, get a white solid product; (2) add POCl3 into the obtained white solid, heated to 80-110 ° C, refluxed with stirring for 5-15 hours, cooled, carefully poured into cold water and ammonia, maintaining the temperature 20-35 ° C, The pH value in the bath adjusted to 10.0-11.5 with ammonia, and distilled under reduced pressure to give the compound 2-chloro-4-methylpyridine; (3) use CCl4 as a solvent,   dropwise SO2Cl2 in the compound of 2-chloro-4-methylpyridine, Adding the radical initiator in batches during the dropwise addition, reacting for 2-8 hours, after cool down the temperature, adjusting the PH value to 6.0-8.0 with saturated sodium bicarbonate, the compound 2-chloro-4-chloromethylpyridine is obtained by distillation under reduced pressure; (4) using DMF as a solvent, potassium carbonate as an acid-binding agent, 2-chloro -4-chloromethylpyridine is condensed with piperidine to give Lafutidine pyridine ethanedioate CAS number  406484-56-8,2-Chloro-4-(1-piperidinylmethyl)pyridine ethanedioate.

Thera. Category:Antiulcerative 

Cas No.:406484-56-8

Synonym: 2-Chloro-4-(1-piperidinylmethyl)pyridine ethanedioate; 2-Chloro-4-(piperidin-1-ylMethyl)pyridine Oxalate

406484-56-8

Molecular Formula: C11H15ClN2.C2H2O4

Molecular Weight:301

Pharmacopeia: In house Spec.

Specifications:Available on request

Packing:Export worthy packing

Material Safety Data Sheet:Available on request

Usage :Intermediates for Lafutifine

Competitive Advantage: Good quality and favorable price

Related intermediate of Lafutidine

1) 4-Nitrophenyl 2-(furfurylsulfinyl)acetic acid CAS 123855-55-0)

2) N-{4-[4-(Piperidinomethyl)pyridyl-2-oxy]-cis-2-butene}phthalimide maleic acid CAS 146447-26-9

3)  2-Chloroisonicotinic acid CAS 6313-54-8

4) 406484-56-8,2-Chloro-4-(1-piperidinylmethyl)pyridine Ethanedioate

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