|Unit Price:||USD 1.0000 / Kilogram |
|Min. Order:||1 Kilogram|
|Delivery Time:||15 Days|
Model No.: 6547-25-1
Packaging: AS REQUIRED
Place of Origin: CHINA
Supply Ability: TRUE MANUFACTURER
2-[( Diphenyl methyl)sulfinyl] acetic acid methyl ester is intermediate of modafinil CAS number 63547-25-1. manufacturers automatically withdraw because of too low profits. Some manufacturers cannot compete due to the high cost of their own technical routes. We feel that there is a method that is more suitable for industrial production. His synthesis process is as follows:
1. In a 1000ml three-necked flask equipped with a stirrer, a thermometer, a condensing device, and an exhaust gas absorption device, add 50g of diphenylmethanol, 200ml of 30% hydrochloric acid, and heat the oil bath to control the internal temperature at 55±5°C and quickly within 10±5min. A mixture of 33 ml of 30% hydrochloric acid and 26.5 g of mercaptoacetic acid was added dropwise. After stirring for about 15 minutes, solids precipitated, and the temperature was raised to 96±3° C., and the reaction was incubated for 2 to 2.5 hours. Toluene 500 ml was added, and the internal temperature was increased by heating. About 75°C, the solid was dissolved with stirring and used for the next reaction.
2. Pour the reaction solution obtained in the first step into a 2L separatory funnel, allow it to stand for about 3-5 minutes, separate the layers, and remove the lower layer of water completely. Transfer the upper toluene layer to the other with stirring, condenser, and thermometer. Tail gas absorption device in a 1L triple reaction flask.
The toluene solution of diphenylmethyl thioacetic acid was heated in an oil bath to 75±5° C., and 70 ml of thionyl chloride and 40 ml of a toluene solution were added dropwise at this temperature. The solution was dropped within 15±5 minutes, and then washed with 10 ml of toluene. The pressure dropping funnel was used for the heat preservation reaction for 2.5 hours, cooled to below 10°C with ice water, and the toluene solution of dibenzylthioacetyl chloride was sealed and stored.
3. In a 2L three-mouth reaction flask with a stirrer and thermometer, add 360ml of ≥28% ammonia, cool to below 0°C in an ice-salt bath, add 430ml of constant water at 0-5°C, and drop at <10°C. The toluene solution of benzhydryl acetyl chloride was added dropwise with vigorous stirring and completed dropwise within 0.8±0.2 h. The reaction was stirred at <10° C. for about 1.0 h, filtered, and the filter cake was washed with purified water to about pH 7. After filtration, the mixture was dried in a baking oven at 60° C. for 6-8 hours to obtain 60.0-65.0 g of Modafinil Carboxylate Methyl Ester .Since 2017, the supply of Modafinil Carboxylate Methyl Ester has been significantly insufficient, and supply and demand have been very tight. It is recommended that the buyer make a purchase plan 2 months in advance.
As competition in the market continues to increase, there are fewer and fewer manufacturers of Modafinil Carboxylate Methyl Ester cas 63547-25-1 , both of which are affected by cost and profit factors as well as too stringent environmental protection policies. Some
Thera. Category: Anti-psychotics
Cas No.: 6547-25-1
Synonym: methyl 2-(benzhydrylsulfinyl)acetate;Methyl (benzhydrylsulfinyl)acetate;2-[(Diphenylmethyl)sulfinyl]acetic Acid Methyl Ester;Modafinil Carboxylate Methyl Ester;(Benzhydrylsulfinyl)acetic acid methyl ester;2-(Benzhydrylsulfinyl)acetic acid methyl ester;Acetic acid, 2-[(diphenylMethyl) sulfinyl]-, Methyl ester;
Appearance: White Crystalline solid
Packing:Export worthy packing
Material Safety Data Sheet:Available on request