4-Bromocrotonic Acid For Making Afatinib CAS 13991-36-1

Unit Price: USD 2000.0000 / Kilogram
Payment Type: T/T
Incoterm: CIF
Min. Order: 1 Kilogram
Delivery Time: 15 Days

Basic Info

Model No.: 13991-36-1

Additional Info

Packaging: AS REQUIRED

Productivity: KGS


Transportation: Air,DHL

Place of Origin: CHINA


Certificate: ISO

Product Description

Afatinib intermediate 4 as known as 4-Bromocrotonic acid CAS number is 13991-36-1, appearance is white solid. in actual production of afatinib,almost no manufacturers use 4-bromocrotonate acid in the route method. Once in a patent literature record one step of amidation reaction of synthesis afatinib which use 4- bromocrotonic acid as raw material,but the reaction yield is very low, maximum only reach 50%, and there was no manufacturer who commercial on production of 4-bromocrotonate acid CAS 13991-36-1, causing difficulties in raw material procurement, so this method was not suitable at that time. Through our effort, we realize our mass production, and make effective exploration of the patent, we think it is a lot of room for improvement. For the customer who has the intention of purchasing 4- bromocrotonate acid for the synthesis of afatinib, we will discuss a method without reservation aspects of the afatinib experience.

Thera. Category:Anti- cancer

Cas No.: 13991-36-1

Synonym:(E)-4-Bromo-2-butenoic acid;(E)-4-Bromocrotonic acid;2-Butenoic acid,4-broMo-, (2E)-;r-bromocrotonic acid;TRANS-4-BROMO-2-BUTENOIC ACID;2-Butenoic acid, 4-bromo-, (E)-;4-BroMobut-2-enoic acid;(2E)-4-Bromo-2-butenoic acid;

Molecular Formula: C4H5BrO2


Molecular Weight: 164.99

Assay: ≥98.%

Packing: Export worthy packing

Material Safety Data Sheet: Available on request

Usage: Intermediate of Afatinib

Related Intermediates :
1. CAS 162012-69-3, 7-Fluoro-6-nitro-4-hydroxyquinazoline
2. CAS 16499-57-3, 7-Fluoroquinazolin-4(3H)-one

         3CAS 162012-67-1, 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro- ,

        4.  4-Bromocrotonic acid CAS number 13991-36-1,

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