| Payment Type: | L/C,T/T |
|---|---|
| Incoterm: | FOB |
| Min. Order: | 1 Kilogram |
| Delivery Time: | 15 Days |
Basic Info
Model No.: 183133-96-2
Additional Info
Packaging: AS REQUIRED
Productivity: KGS
Brand: VOLSENCHEM
Transportation: Air
Place of Origin: CHINA
Supply Ability: TRUE MANUFACTURER
Certificate: ISO
Product Description
Cabazitaxel CAS number is183133-96-2, a chemically semisynthetic small molecule compound, was approved in the United States in June 2010 and is a second-line anti-prostate cancer drug. The anticancer mechanism and characteristics of Cabazitaxel similar to docetaxel, belongs to anti-microtubule drugs. Through the combination with tubulin, it promotes its assembly into microtubules, while preventing the assembled microtubules from disintegrating, stabilizing the microtubules, thereby inhibiting the mitosis of cells and the interphase cell function, and it is the first to use Commonly used advanced prostate cancer drug docetaxel ineffective or even worse when the preferred treatment of advanced, anti-prostate cancer drugs. Cabazitaxel offers a novel treatment for castration resistant prostate cancer patients, prompting hope for prostate cancer patients, although only modest gains have been achieved, confirming the effectiveness of immunotherapy for prostate cancer. Cabazitaxel CAS number 183133-96-2 is known to exist in a variety of crystalline forms that directly affect the drug's formulation processability and affect the stability, solubility and bioavailability of the drug, thereby affecting the quality, safety, availability of the drug and its application. His anhydrous crystalline form has a wide range of applications.
As can be seen from the existing patents, the main difficulty in the preparation of cabazitaxel lies in the first step C-7, C-10 methylation of paclitaxel extract 10-DAB, which can introduce a large amount of by-products, The temperature and reagent requirements are more stringent. The use of 7,10-bis-methoxy-10-DAB as a starting material for the preparation of cabazitaxel can shorten the reaction cycle, reduce the production difficulty of enterprises, which will benefit the realization of the latter part of industrialized production.
Thera. Category: Anti-cancer
Cas No.: 183133-96-2
Synonym: Cabazitaxel;TXD-258; Cabazitaxel(XRP-6258)
Molecular Weight: 835.93238
Molecular formula: C45H57NO14
Assay: ≥98.%
Appearance: White Crystalline solid
Packing:Export worthy packing
Material Safety Data Sheet:Available on request
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