4-(Isopropylamino)Butan-1-Ol For Selexipag CAS Number 42042-71-7

Basic Info

Model No.: 42042-71-7

Additional Info

Packaging: AS REQUIRED

Productivity: G,KGS,

Brand: VOLSENCHEM

Transportation: Air

Place of Origin: CHINA

Supply Ability: COMMERCIAL PRODUCTION

Certificate: GMP/ISO

Product Description

Selexipag Intermediate has the chemical name of 4-(Isopropylamino)butan-1-ol CAS number is 42042-71-7. It is a basic intermediate of Selexipag. It was reported as a starting material for the first reaction in some reports. The general procedure of this method is as follows: use 4-(Isopropylamino)butan-1-ol and 5-chloro-2,3-diphenylpyridine Triazine as raw material, through the substitution, coupling, condensation and other multi-step reaction, made the functional groups continue to superposition, then get the target product Selexipag. this method has three disadvantages: 1. The amount of 4-(Isopropylamino)butan-1-ol used in the first step of the substitution reaction is larger and the cost is higher. 2. Since 4-(Isopropylamino)butan-1-ol is used as a starting material, its structure has -NH and -OH groups, so that the first step of the substitution reaction produces competitive side reactions at different positions, introduces impurities, The quality of downstream intermediates and products and purification processes are adversely affected, resulting in complex and cumbersome operations. 3. Due to the large amount of 4-(Isopropylamino)butan-1-ol used, its reaction temperature with 5-chloro-2,3-diphenylpyrazine is relatively high, making it prone to danger. Therefore, this method is not conducive to enlarge production and industrialization promotion.
Based on the above shortcomings ,some people slightly adjusted the before two-step reaction. Use 5-chloro-2,3-diphenylpyrazine as raw material ,through a one-step reaction to give 5-iodo-2,3-diphenylpyridine, which is then reacted with 4-(Isopropylamino)butan-1-ol to give the corresponding product. This small adjustment greatly reduces the amount of 4-(Isopropylamino)butan-1-ol used and Produce fewer by-products, the reaction time is significantly reduced.

Thera. Category: Anti-depression

Cas No.: 42042-71-7

Synonym: 4-(Isopropylamino)butan-1-ol;4-(propan-2-ylamino)butan-1-ol;1-Butanol, 4-(isopropylamino)-;4-[(1-Methylethyl)amino]-1-butanol;4-(Isopropylamino)butanol;4-hydroxy-N-isopropylbutan-1-aMine;

Molecular Formula: C7H17NO

Molecular Weight: 131.21598

Specifications: Available on request

Packing: Export worthy packing

Material Safety Data Sheet: Available on request

Usage: Selexipag is a drug currently in development by Actelion as a treatment of pulmonary arterial hypertension