5-Chloro-2,3-Diphenylpyrazine Used for Selexipag Cas Number 41270-66-0

Payment Type: T/T
Incoterm: CIF
Min. Order: 1 Gram
Delivery Time: 20 Days

Basic Info

Model No.: 41270-66-0

Additional Info

Packaging: AS REQUIRED

Productivity: G,KGS,


Transportation: Air

Place of Origin: CHINA


Certificate: GMP/ISO

Product Description

5-chloro-2,3-diphenylpyrazine cas number is 41270-66-0 which is used for Selexipag, There are different uses for the different synthesis solutions in Selexipag. To summarize there are two main uses: 1. use 5-chloro-2,3-diphenylpyrazine as raw material, by substitution, coupling, condensation and other multi-step reaction to produce the final product Selexipag. The disadvantage of this method is that the pyrazine core structure is introduced in the first step of reaction using 5-chloro-2,3-diphenylpyrazine as raw material, which will produce a large amount of by-products so as to be detrimental to the purification of the intermediate . 2. Starting from 4- [(tert-butoxycarbonyl) (isopropyl) amino] -1-butanol and tert-butyl bromoacetate by condensation, hydrolysis and re-condensation, 2- [4- (Isopropyl) aminobutoxy] -N- (methylsulfonyl) acetamide (N- (methylsulfonyl) acetamide side chain compound) was obtained after deprotection with 5-chloro-2,3- Diphenyl-pyrazine cas number 41270-66-0 by substitution reaction to the preparation of Selexipag. The advantages of this operation are as follows: 1 since the reaction is completed only need the conventional post-processing and purification without the need for purification of the column, fewer impurities, controllable, can be directly carried out the next reaction, thus simplifying the operation, At the same time each step can get a higher yield. 2. In the preparation process does not produce pollutants, in line with the current green production environment policy. Therefore, this technical solution is very reasonable.

Thera. Category: Anti-depression

Cas No.: 41270-66-0

Synonym: 2-Chloro-5,6-diphenylpyrazine


Molecular Formula: C16H11ClN2

Molecular Weight: 266.72494

Specifications: Available on request

Packing: Export worthy packing

Material Safety Data Sheet: Available on request

Usage: Selexipag is a drug currently in development by Actelion as a treatment of pulmonary arterial hypertension


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