|Unit Price:||USD 1.0000 / Kilogram |
|Min. Order:||1 Kilogram|
|Delivery Time:||15 Days|
Model No.: 1256698-41-5
Packaging: AS REQUIRED
Place of Origin: CHINA
Supply Ability: TRUE MANUFACTURER
Alectinib intermediate 3 CAS number is 1256698-41-5, his synthesis process often has the defects that the starting materials are relatively expensive and difficult to obtain, the final product has more impurities and by-products, and the operation is cumbersome. There is a more classical method for synthesizing erlotinib intermediate 3, the specific process is as follows:
First, 6-bromo-7-methoxy-3,4-dihydro-2-naphthalenone is used as a raw material to carry out hydrolysis to obtain methoxy deprotection, and further, trifluoromethanesulfonic acid by trifluoromethanesulfonic anhydride Esterification gives the corresponding Trimethylsilyl trifluoromethanesulfonate compound followed by dimethylation and subsequent substitution with another starting material, 4-(4-piperidinyl)morpholine, by synthesis using the classical reaction Fischer indo synthesis method. The carbonyl group and benzoquinone are cyclized under acid catalysis to form a ruthenium nucleus. Finally, the target compound Alectinib intermediate 3 CAS number 1256698-41-5 is obtained by oxidation reaction. The route design is reasonable and special, the raw materials are cheap and easy to obtain, and the reaction conditions are easy and effective control.
This method has the following advantages: First, since each step of the reaction is completed, only regular post-treatment and purification are performed without purification of the column, and the impurities are less and controllable, and the next reaction can be directly performed. The operation is simplified, and the higher yield is obtained in each step. Secondly, the starting materials and the reagents used are easily available, the technical scheme of the synthesis reaction is reasonable, and the mass production can be carried out to meet the demand of the raw material medicine, and is suitable for industrialization production; Third, because it does not produce pollutants during the preparation process, it is in line with the current concept of green production.
Thera. Category: Anti cancer
Cas No.: 1256698-41-5
Synonyms: Alectinib intermediate;6-Cyano-2-[1-[4-ethyl-3-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-1-methylethyl]-1H-indole-3-carboxylic acid 1,1-dimethylethyl ester
Packing: Export worthy packing
Material Safety Data Sheet: Available on request