|Unit Price:||USD 1.0000 / Kilogram |
|Min. Order:||1 Kilogram|
|Delivery Time:||15 Days|
Model No.: 1256589-74-8
Packaging: AS REQUIRED
Place of Origin: CHINA
Supply Ability: TRUE MANUFACTURER
The new anaplastic lymphoma kinase (ALK) inhibitor Alectinib hydrochloride CAS 1256589-74-8, It has been obtained the FDA breakthrough therapeutic drug qualification, accelerated approval as a new oral anti-lung cancer drug for the treatment of ALK gene mutation Advanced metastatic non-small cell lung cancer. It has high efficiency in inhibiting tumor activity and high safety. Its comprehensive preclinical studies have shown that oral Alectinib is safe, its molecular mechanism of anti-tumor effect is clear, and it is highly specific and specific, and its inhibitory effect on EGFR/ErbB1 and ErbB2 tyrosine kinase is obvious. Solid malignant tumors such as cell lung cancer have significant curative effects, and are also suitable for patients who have deteriorated or are not tolerated after treatment with another therapeutic drug, crizotinib. It was approved by the US FDA in December 2015.
In the literature report, there are two main methods for the synthesis of Alectinib hydrochloride CAS 1256589-74-8. The first one is based on 7-methoxy-3,4-dihydronaphthalene-2(1H)-one. Through 8 Step reaction to obtain. This method constructs an anthracene ring through phenylhydrazine to finally complete the synthesis of Alectinib hydrochloride. The route design of this method is too long and the total product yield is too low.
The second method is prepared by 5-step reaction using 3-iodo-4-ethyl-tert-butylbenzene as a starting material. This method is carried out by reduction of m-cyanonitrobenzene to an amino group to form an anthracene ring, which is finally completed Synthesis of Alectinib hydrochloride.
The core of these two methods are synthetic anthracene rings. However, due to the multiple functional groups of the substrate, the reaction process is quite complicated, the purification is difficult, and the total yield of the reaction is greatly limited by the step of synthesizing the anthracene ring. Aiming at the defects existing in the existing technology, it is of practical significance to develop a new and simple process and find a process technology that can adapt to industrial production,It has practical significance for large-scale application of Alectinib hydrochloride CAS 1256589-74-8.
Thera. Category: Anti Cancer
Cas No.: 1256589-74-8
Synonyms: AF-802 Hydrochloride;Alectinib Hydrochloride;CH5424802 Hydrochloride;CH-5424802 Hydrochloride;RG-7853 Hydrochloride
Packing: Export worthy packing
Material Safety Data Sheet: Available on request