Brigatinib Intermediates CAS 1197953-49-3

Unit Price: USD 1.0000 / Kilogram
Payment Type: T/T
Incoterm: CIF
Min. Order: 1 Kilogram
Delivery Time: 15 Days

Basic Info

Model No.: 1197953-49-3

Additional Info

Packaging: AS REQUIRED

Productivity: KGS


Transportation: Air

Place of Origin: CHINA


Product Description

AP26113 Intermediate 5 CAS number is 1197953-49-3. it is an important intermediate for the synthesis of AP26113. We found the relevant information in the literature reported its synthetic route, roughly use 2,4,5-trichloropyrimidine and 2- (dimethyl oxophosphonium) aniline as the raw material to replace the reaction to produce the target compound. Although the synthesis of this route is relatively simple, but there are three chlorine atoms on 2,4,5-trichloropyrimidine has little difference on the nucleophilic activity,when in the face of the same or similar aniline groups, the location of selectively will inevitably produce interference, resulting in unnecessary side effects, thus affecting the quality of the product. At the same time, the use of precious metal palladium reagents during the reaction also increases the manufacturing cost and is not conducive to its industrialization.
Thera. Category: Anti-cancer

Cas No.:1197953-54-0

Synonyms: AP26113 Intermediate 1;2,5-dichloro-N-(2-(diMethylphosphoryl)phenyl)pyriMidin-4-aMine;(2-((2,5-dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide;4-(orthodimethylphosphinylanilino)-5-chloro-2-chloropyrimidine


Molecular Formula:C12H12Cl2N3O3P

Molecular Weight: 348.121741

Purity: ≥98%

Packing: Export worthy packing

Material Safety Data Sheet: Available on request 









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