Canagliflozin Intermediate 3 CAS 898566-17-1

Unit Price: USD 1.0000 / Kilogram
Payment Type: T/T
Incoterm: CIF
Min. Order: 1 Kilogram
Delivery Time: 15 Days

Basic Info

Model No.: 898566-17-1

Additional Info

Packaging: AS REQUIRED

Productivity: KGS


Transportation: Air

Place of Origin: CHINA


Product Description

Canagliflozin Intermediate 3 CAS number 898566-17-1, it is necessary intermediate when produce canagliflozin, Regarding its synthesis, we have consulted the relevant literature, in which the U.S. Patent No. 20050233988A1 discloses a synthetic route. We think that the shortcoming of this route is as following: 1.Suzuki coupling need to use expensive Pd or Ni reagent catalyst, and the reaction of the raw material itself is difficult to control, not suitable for industrial production. 2. Friedel–Crafts reaction is difficult to complete reaction, the remaining raw materials is difficult to purify, and the product purity is low, and the yield is low. Application of CN102115468B patent also reported the preparation of the Canagliflozin intermediate 3, we believe that its shortcomings are as below: 1. The raw materials triethylsilane used is in high prices, high cost. 2. Boron trifluoride ether and triethyl silane have a pungent odor, high environmental requirements, do not meet the increasingly tightening of environmental protection policy. After a comprehensive analysis, we believe that the preparation of fluorobenzyl and 3-haloacrolein as the starting material is more in line with the requirements of industrial production.

Thera. CategoryTreatment of type 2 diabetes

Cas No.898566-17-1

SynonymCanagliflozin INT5;Canagliflozin Intermediate1


Molecular FormulaC18H14FIS

Molecular Weight: 408.27


PackingExport worthy packing

lMaterial Safety Data SheetAvailable on request

UsageIntermediate of Canagliflozin
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