Canagliflozin Intermediate 4 CAS Number 1030825-20-7

Unit Price: USD 1.0000 / Kilogram
Payment Type: T/T
Incoterm: CIF
Min. Order: 1 Kilogram
Delivery Time: 15 Days

Basic Info

Model No.: 1030825-20-7

Additional Info

Packaging: AS REQUIRED

Productivity: KGS


Transportation: Air

Place of Origin: CHINA


Product Description

Canagliflozin Intermediate 4 CAS number 1030825-20-7, It is an important intermediate for the synthesis of Canagliflozin, so it is particularly important to find a best preparation method for t Canagliflozin intermediate 4 CAS 1030825-20-7. We have found a patent for the patent number CN102115468B discloses a synthetic method, use 2-bromo-1-(5-bromo-2-methylphenyl) ethanone and (Z) -3-bromo-3- (4-fluorophenyl) ethanone an as the raw material, through two-step reaction can be get the target product. But we believe that the shortcomings of this method is as below: 1. two starting materials are not easy to buy, and the price is high. 2. The purity of target product is low, it is difficult to meet the buyer's quality requirements. There are related reports in the literature that use 1-(5-bromo-2-methylphenyl) -2-iodoethanone and (E) -3- (dimethylamino) -1- (4-fluorophenyl) prop-2-ene-1-thione as starting material. The starting materials were prepared by two steps to produce the target product, but after our experiments, the yield was only 50% and the raw materials were relatively expensive. After our repeated experiments, we believe that 2- (4-fluorophenyl) thiophene and 5-bromo-2-methylbenzaldehyde as raw materials in n-butyl lithium catalyst to get the target product of the oxide, and then through the reduction of the target product ,This method is suitable for industrial production.

Thera. CategoryTreatment of type 2 diabetes

Cas No.1030825-20-7

Synonym:2-[(5-broMo-2-Methylphenyl)Methyl]-5-(4-fluorophenyl)-;Canogliflozin;Canagliflozin Intermediate II;2-(5-bromo-2-methyl-benzyl-(5-fluorophenyl)thiophene;Canagliflozin INT4;Canagliflozin Intermediate2;2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene;2-[(5-Bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene;Thiophene,


Molecular Formula:C18H14BrFS

Molecular Weight:361.2711632


PackingExport worthy packing

lMaterial Safety Data SheetAvailable on request

UsageIntermediate of Canagliflozin
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