Cas 103041-38-9,3-(Pyridin-2-ylaMino)-Propionic Acid Ethyl Ester

Payment Type: L/C,T/T
Incoterm: FOB
Min. Order: 1 Kilogram
Delivery Time: 15 Days

Basic Info

Model No.: 103041-38-9

Additional Info

Packaging: AS REQUIRED

Productivity: KGS


Transportation: Air

Place of Origin: CHINA

Supply Ability: 100KG

Certificate: ISO

Product Description

Dabigatran etexilate intermediate with the chemical name of 3-(Pyridin-2-ylaMino)-propionic acid ethyl ester CAS number 103041-38-9,Exactly speaking,it is the side chain of the intermediate of dabigatran etexilate in the fifth step. The appearance is off-white to white powder. Its usually produces the fifth step intermediate of dabigatran etexilate by reaction with 3-bromo-4- (methylamino) benzoic acid,details as follows: 34.4 g of 3-bromo-4- (methylamino),mixed with 240 mL of dichloromethane at room temperature and stirred for 1 hour and cooled to -20 ° C. 12.0 mL of thionyl chloride was added and then about 0.5 mL of N, N-dimethylformamide was added dropwise to continue the reaction for 4 hours. Until naturally rising to room temperature, then 29.12gram of ethyl 3- (pyridin-2-ylamino) propionate , 41.7ml were added, continued reaction for 6 hours at room temperature, the reaction was terminated by adding 300 mL of water, the organic layer was separated, The mixture was further washed with 200 mL of saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate and concentrated under reduced pressure to a total volume of about 100 mL. 50 mL of n-hexane was added to precipitate a solid which was stirred for 2.5 hours at room temperature. Vacumn Dried for 1 hour to give a white solid 57.7 g, this white solid was dabigatran etexilate intermediate N-5.

Thera. Category: Antithrombotic/Blood thinners

Cas No.:103041-38-9

Synonym:ethyl (2S)-2-[(pyridin-2-yl)aMino]propanoate;3-(Pyridin-2-ylaMino)-propionic acid ethyl ester;Ethyl 3-(2-PyridylaMino)propanoate;N-Ethyl 3-(pyridin-2-ylaMino)propanoate;N-[2]PYRIDYL-B-ALANIN-ETHYL ESTER;N-2-pyridinyl-β-Alanine,ethylester;ethyl 3-(pyridin-2-ylamino)propanoate;N-Pyridin-2-yl-beta-alanine ethyl ester;


Molecular Weight:194.23036

Molecular formula:C10H14N2O2

Purity: ≥99.%

Appearance: White Crystalline solid

Packing:Export worthy packing

Material Safety Data Sheet:Available on request

Usage: It can treat and prevent blood clots, reducing the risk of stroke.

Related intermediate:

Chemical Name Specification Color
41263-74-5 4-(MethylaMino)-3-nitrobenzoic acid HPLC 99.0% pale brown
           103041-38-9 N-[2]PYRIDYL-B-ALANIN-ETHYL ESTER HPLC 99.0% off white to white
           429659-01-8 ETHYL N-[4-(METHYLAMINO)-3-NITROBENZOYL]-N-PYRIDIN-2-YL-SS-ALANINATE HPLC 99.0% orange yellow solid 
N-(4-CYANO-PHENYL)-GLYCINE HPLC 99.0%  off white  
Loss on drying 1.0%
Melting point 101.0°C~106.0°C
Single impurity 0.3% 
Loss on drying 0.5%
Residue on ignition 0.5% 
Assay 98.0%
Synonyms:3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino]propionic acid ethyl ester HPLC 99.0% off white  
Single impurity 0.3%
Loss on drying 0.5% 
Residue on ignition 0.5% 
Assay 99.0%
 872728-85-3 N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]arbonyl]-N-2-pyridinyl-beta-alanine ethyl ester 4-methylbenzenesulfonate HPLC 97.0% off white  
Dabigatran Etexilate HPLC 98.0%  white  
Single impurity 0.2%
Loss on drying 1.0% 
Assay 98.0%
Dabigatran etexilate mesylate HPLC 99.0%  light yellow solid
Single impurity 0.5%
Loss on drying 1.0% 
Residue on ignition 0.1% 
Heavy melta 20 ppm 
Assay 98.5%

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