Payment Type: | L/C,T/T |
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Incoterm: | FOB |
Min. Order: | 1 Kilogram |
Delivery Time: | 15 Days |
Basic Info
Model No.: 41263-74-5
Additional Info
Packaging: AS REQUIRED
Productivity: KGS
Brand: VOLSENCHEM
Transportation: Air
Place of Origin: CHINA
Supply Ability: 100KG
Certificate: ISO
Product Description
Dabigatran etexilate intermediate has the chemical name of 4-(MethylaMino)-3-Nitrobenzoic Acid CAS number is 41263-74-5, Use 4-(MethylaMino)-3-Nitrobenzoic Acid as raw materials for the synthesis of dabigatran etexilate are the most widely method which reported in the literature, this method has the advantage of low prices of raw materials, but 4-methylamino-3-nitrobenzoic acid and N-Ethyl 3-(pyridin-2-ylaMino)propanoate will cause vice Products during the process of condensation, it needs for recrystallization and purification in order to carry out the next reaction. In addition, the condensed product needs to be reduced to an amino group by a nitro group. This reaction requires the catalytic hydrogenation of palladium on carbon. Because hydrogen is flammable and explosive, it is dangerous to enlarge the operation of this step. So the shortcomings of this method is also more obvious. Therefore, it is still necessary to further optimize the reaction steps to explore the best reaction time and reaction temperature to control the occurrence of by-products.
Some people adjusted the first step of this synthesis reaction ,use 4-methylamino-3-nitrobenzoic acid as raw material, added SOCl2, together heated to 81-84 ° C, reflux 2 ~ 4 h, remove excess SOCl2, get the compound of 3-nitro-4-methylaminobenzoyl chloride, the method of the reaction conditions are mild, has no other by-products, the product can be directly carried out the next reaction. This greatly simplifies the operation.
Thera. Category: Antithrombotic/Blood thinners
Cas No.:41263-74-5
Synonym:Benzoic acid, 4-(MethylaMino)-3-nitro-;Dabigatran Etexilate Intermediate 5;4-(METHYLAMINO)-3-NITROBENZOIC ACID;NSC 138300;4-(MethylaMino)-3-nitrobenzoic acid 98%;
Molecular Weight:196.16
Molecular formula: C8H8N2O4
Purity: ≥98.%
Appearance: White Crystalline solid
Packing:Export worthy packing
Material Safety Data Sheet:Available on request
Usage: It can treat and prevent blood clots, reducing the risk of stroke.
Related intermediate:
CAS |
Chemical Name | Specification | Color | |
41263-74-5 | 4-(MethylaMino)-3-nitrobenzoic acid | HPLC | ≥99.0% | pale brown |
103041-38-9 | N-[2]PYRIDYL-B-ALANIN-ETHYL ESTER | HPLC | ≥99.0% | off white to white |
429659-01-8 | ETHYL N-[4-(METHYLAMINO)-3-NITROBENZOYL]-N-PYRIDIN-2-YL-SS-ALANINATE | HPLC | ≥99.0% | orange yellow solid |
42288-26-6 |
N-(4-CYANO-PHENYL)-GLYCINE | HPLC | ≥99.0% | off white |
Loss on drying | ≤1.0% | |||
212322-56-0 |
3-[(3-AMINO-4-METHYLAMINO-BENZOYL)-PYRIDIN-2-YL-AMINO]-PROPIONIC ACID ETHYL ESTER | HPLC | ≥99.0% | off white |
Melting point | 101.0°C~106.0°C | |||
Single impurity | ≤0.3% | |||
Loss on drying | ≤0.5% | |||
Residue on ignition | ≤0.5% | |||
Assay | ≥98.0% | |||
211915-84-3 |
Synonyms:3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino]propionic acid ethyl ester | HPLC | ≥99.0% | off white |
Single impurity | ≤0.3% | |||
Loss on drying | ≤0.5% | |||
Residue on ignition | ≤0.5% | |||
Assay | ≥99.0% | |||
872728-85-3 | N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]arbonyl]-N-2-pyridinyl-beta-alanine ethyl ester 4-methylbenzenesulfonate | HPLC | ≥97.0% | off white |
211915-06-9 |
Dabigatran Etexilate | HPLC | ≥98.0% | white |
Single impurity | ≤0.2% | |||
Loss on drying | ≤1.0% | |||
Assay | ≥98.0% | |||
872728-81-9 |
Dabigatran etexilate mesylate | HPLC | ≥99.0% | light yellow solid |
Single impurity | ≤0.5% | |||
Loss on drying | ≤1.0% | |||
Residue on ignition | ≤0.1% | |||
Heavy melta | ≤20 ppm | |||
Assay | ≥98.5% |
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