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4-(MethylaMino)-3-Nitrobenzoic Acid Used for Dabigatran Etexilate Mesylate

Payment Type:	L/C,T/T
Incoterm:	FOB
Min. Order:	1 Kilogram
Delivery Time:	15 Days

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Basic Info

Model No.: 41263-74-5

Additional Info

Packaging: AS REQUIRED

Productivity: KGS

Brand: VOLSENCHEM

Transportation: Air

Place of Origin: CHINA

Supply Ability: 100KG

Certificate: ISO

Product Description

Dabigatran etexilate intermediate has the chemical name of 4-(MethylaMino)-3-Nitrobenzoic Acid CAS number is 41263-74-5, Use 4-(MethylaMino)-3-Nitrobenzoic Acid as raw materials for the synthesis of dabigatran etexilate are the most widely method which reported in the literature, this method has the advantage of low prices of raw materials, but 4-methylamino-3-nitrobenzoic acid and N-Ethyl 3-(pyridin-2-ylaMino)propanoate will cause vice Products during the process of condensation, it needs for recrystallization and purification in order to carry out the next reaction. In addition, the condensed product needs to be reduced to an amino group by a nitro group. This reaction requires the catalytic hydrogenation of palladium on carbon. Because hydrogen is flammable and explosive, it is dangerous to enlarge the operation of this step. So the shortcomings of this method is also more obvious. Therefore, it is still necessary to further optimize the reaction steps to explore the best reaction time and reaction temperature to control the occurrence of by-products.
Some people adjusted the first step of this synthesis reaction ,use 4-methylamino-3-nitrobenzoic acid as raw material, added SOCl2, together heated to 81-84 ° C, reflux 2 ~ 4 h, remove excess SOCl2, get the compound of 3-nitro-4-methylaminobenzoyl chloride, the method of the reaction conditions are mild, has no other by-products, the product can be directly carried out the next reaction. This greatly simplifies the operation.

Thera. Category: Antithrombotic/Blood thinners

Cas No.:41263-74-5

Synonym:Benzoic acid, 4-(MethylaMino)-3-nitro-;Dabigatran Etexilate Intermediate 5;4-(METHYLAMINO)-3-NITROBENZOIC ACID;NSC 138300;4-(MethylaMino)-3-nitrobenzoic acid 98%;

41263-74-5

Molecular Weight:196.16

Molecular formula: C8H8N2O4

Purity: ≥98.%

Appearance: White Crystalline solid

Packing:Export worthy packing

Material Safety Data Sheet:Available on request

Usage: It can treat and prevent blood clots, reducing the risk of stroke.

Related intermediate:

CAS	Chemical Name	Specification		Color
41263-74-5	4-(MethylaMino)-3-nitrobenzoic acid	HPLC	≥99.0%	pale brown
103041-38-9	N-[2]PYRIDYL-B-ALANIN-ETHYL ESTER	HPLC	≥99.0%	off white to white
429659-01-8	ETHYL N-[4-(METHYLAMINO)-3-NITROBENZOYL]-N-PYRIDIN-2-YL-SS-ALANINATE	HPLC	≥99.0%	orange yellow solid
42288-26-6	N-(4-CYANO-PHENYL)-GLYCINE	HPLC	≥99.0%	off white
42288-26-6	N-(4-CYANO-PHENYL)-GLYCINE	Loss on drying	≤1.0%	off white
212322-56-0	3-[(3-AMINO-4-METHYLAMINO-BENZOYL)-PYRIDIN-2-YL-AMINO]-PROPIONIC ACID ETHYL ESTER	HPLC	≥99.0%	off white
		Melting point	101.0°C~106.0°C
		Single impurity	≤0.3%
		Loss on drying	≤0.5%
		Residue on ignition	≤0.5%
		Assay	≥98.0%
211915-84-3	Synonyms:3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino]propionic acid ethyl ester	HPLC	≥99.0%	off white
		Single impurity	≤0.3%
		Loss on drying	≤0.5%
		Residue on ignition	≤0.5%
		Assay	≥99.0%
872728-85-3	N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]arbonyl]-N-2-pyridinyl-beta-alanine ethyl ester 4-methylbenzenesulfonate	HPLC	≥97.0%	off white
211915-06-9	Dabigatran Etexilate	HPLC	≥98.0%	white
		Single impurity	≤0.2%
		Loss on drying	≤1.0%
		Assay	≥98.0%
872728-81-9	Dabigatran etexilate mesylate	HPLC	≥99.0%	light yellow solid
		Single impurity	≤0.5%
		Loss on drying	≤1.0%
		Residue on ignition	≤0.1%
		Heavy melta	≤20 ppm
		Assay	≥98.5%

41263 74 5 CAS 41263 74 5 CAS Number 41263 74 5

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