CAS 1032903-50-6,Ceritinib Intermediate

Basic Info

Model No.: 1032903-50-6

Additional Info

Packaging: AS REQUIRED

Productivity: KGS

Brand: VOLSENCHEM

Place of Origin: CHINA

Supply Ability: TRUE MANUFACTURER

Certificate: ISO

Product Description

The Ceritinib intermediate cas number 1032903-50-6 synthesis of experimental steps are as follows: use 2-chloro-4-fluorotoluene as raw materials, through one step reaction to get the first step intermediate of 2-chloro-4-fluoro-5-nitrotoluene. As we had been detained description of  2-chloro-4-fluoro-5-nitrotoluene, so we do not repeat here. We will detail introduce the second step of the reaction process,dissolved the first step intermediate2-chloro-4-fluoro-5-nitrotoluen in 1200ml isopropanol and then added to 2L three bottles. Add 429 g of anhydrous potassium carbonate powder and stir to raise temperature to reflux. The reaction was allowed to proceed under reflux for 30 hours. Concentrate to remove most of the isopropanol. Add 2L of water, extracted twice with ethyl acetate, combined with ethyl acetate, washed with water. Ethyl acetate was concentrated to give the final brown product 1-Chloro-5-isopropoxy-2-methyl-4-nitrobenzene cas number 1032903-50-6.

l Thera. Category:Anti- cancer

l Cas No.: 1032903-50-6

l Synonym:(S)-N-tert-Butoxycarbonyl-3-hydroxypiperidine

l Molecular Formula:C₁₀H₁₂ClNO₃

l Molecular Weight:229.66

l Assay: ≥98.%

l Packing:Export worthy packing

l Material Safety Data Sheet:Available on request

l Usage: Intermediate of Cerutinib

Related Intermediates : 

CAS 1032903-50-6,1-Chloro-5-isopropoxy-2-methyl-4-nitrobenzene 

CAS 76697-50-2,1-Amino-2-(isopropylsulphonyl)benzene

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2-chloro-4-fluoro-5-nitrotoluene CAS number 112108-73-3

[2-(isopropylthio)phenyl]amine hydrochloride CAS number  861343-73-9