Cholesterol Transport Inhibitor Ezetimibe CAS 163222-33-1

Basic Info

Model No.: 163222-33-1

Additional Info

Packaging: AS REQUIRED

Productivity: KGS

Brand: VOLSENCHEM

Transportation: Air

Place of Origin: CHINA

Supply Ability: TRUE MANUFACTURER

Product Description

Ezetimibe cas number is 163222-33-1, it was the first to receive the US FDA approved listing of cholesterol absorption selective inhibitor drugs. Ezetimibe is a new class of selective cholesterol absorption inhibitors, but also the first intestinal cholesterol absorption of selective inhibitors, and its mechanism of action and other lipid-lowering drugs, such as statins, cholic acid chelating agents, Phenoxy acid derivatives and plant sterol esters. Ezetimibe through binding the small intestine brush-like membranous membrane vesicle membrane protein , inhibition of small intestine diet and by the bile to the intestinal tract of cholesterol absorption, reduce serum and liver cholesterol levels. Unlike cholic acid chelating agents, ezetimibe does not affect the absorption of cholesterol esters, other steroids (such as bovine cholic acid), triglyceride and fat-soluble vitamins. The pharmacological effects were not related to the inhibition of acetyl-CoA-cholesterol acetyltransferase (ACAT) and the expression of LDL receptor (scavenger receptor). Ezetimibe is absorbed in the liver after combined with glucuronic acid by the hepatic bowel cycle, almost specifically located in the small intestinal mucosal cells. Ezetimibe cas 163222-33-1 can be used alone or in combination with HMG-CoA reductase inhibitors (statins) for the treatment of primary (heterozygous familial or non familial) hypercholesterolemia, homozygous familial hypercholesterolemia (HoFH), homozygous sitosterol (or phytosterols).

Thera. Category: Lipid-lowering drug

Cas No.: 163222-33-1

Synonym: EZETIMIBE;ZETIA;Ezitimibe∬EzetimibeC24H21F2N03; 1-(4-Flurophenyl)-(3R)-3-(4-flurophenyl)-(3S)-hydroxypropyl-(4S)-(4-hydroxyphenyl)-2-azetidinone;Ezetimide

Molecular Formula:C24H21F2NO3

Molecular Weight: 409.43       

Assay: ≥99.%

Packing: Export worthy packing

lMaterial Safety Data Sheet: Available on request

Usage: Synthesis Pharmaceutical Intermediates

Related intermediate:

1)(3R,4S)-4-[4-(Benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]azetidin-2-one 190595-65-4
2) 2-AZETIDINONE, 1-(4-FLUOROPHENYL)-3-[(3S)-3-(4-FLUOROPHENYL)-3-HYDROXYPROPYL]-4-[4-(PHENYLMETHOXY)PHENYL]-, (3R,4S)- cas 163222-32-0
3) Methyl (3R,4S)-1-(4-fluorophenyl)-2-oxo-4-[4-(phenylmethoxy)phenyl]-3-azetidinepropanoate cas 204589-80-0
4) N-(4- (Benzyloxy) benzylidene) -4-fluoroaniline CAS 70627-52-0 
5) Ezetimibe  163222-33-1