High Purity Sacubitril Calcium Or AHU-377 CAS 1369773-39-6

Basic Info

Model No.: 1369773-39-6

Additional Info

Packaging: AS REQUIRED

Productivity: KGS

Brand: VOLSENCHEM

Transportation: Air

Place of Origin: CHINA

Supply Ability: TRUE MANUFACTURER

Certificate: ISO

Product Description

     Enkephalin inhibitor AHU - 377 OR Sacubitril hemicalcium salt CAS number is 1369773 -39-6, now the common problems in synthesis methods are as following,the price of chiral raw material is high, need to build chiral group in synthesis, the chiral reagent used in the reaction is expensive, operating conditions are harsh, these problems directly cause it is unable to process mass production. It means to the big star product,it is hard to meet the needs of the future market. Some researchers in the study of steroidal saponins and clean oxidation method was successfully recycled from the reaction of chiral compounds (2R, 4R) in the waste -2,5- two hydroxy -4- methyl pentanoic acid, and then further carries on the TBS protection, reduction operation,transfer (2R, 4R -2,5-) two hydroxy -4- methyl valerate into chiral reagent (2R, 4R)  -1,2,5- PENTANETRIOL which protected by 1-TBS and their derivatives, which provides a cheap chiral reagent for AHU-377 CAS1369773-39-6 industrial production. Then use the  chiral reagent as raw material, through 5 steps reaction to Synthesis of AHU-377.  

AHU-377 (heMicalcium salt) CAS 1369773-39-6  with the molecular formula is 2(C24H29NO5).Ca and formula weight 863.08. It is an important product in our company. We are rich experience supplier in China who provide high AHU-377 (hemicalcium salt) CAS 1369773-39-6 and some relation product.  AHU-377 hemicalcium salt CAS NO 1369773-39-6 is a hemicalcium salt form of AHU-377 that is an inhibitor of neprilysin with IC50 value of 5 nM. And AHU-377 (heMicalcium salt) 1369773-39-6 is widely used to synthesis LCZ696. 

Thera. Category: Anti-Hypertensive

Cas No.: 1369773-39-6

Synonym: (alphaR,gammaS)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt (2:1); AHU-377 hemicalcium salt 

Molecular Formula: 2(C24H29NO5).Ca

Molecular Weight: 863.08

Assay: ≥99.%

Packing: Export worthy packing

lMaterial Safety Data Sheet: Available on request

Usage: LCZ(Sacubitril) Intermediates

 (2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoate 149709- 60-4

(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic acid ethyl ester hydrochloride 149690-12-0

 (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid  1012341-50-2

 (R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid 1012341-48-8

(R)-Ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoate. 149709-59-1