Colorless Liquid 3-Methoxypropyl-4-Piperidinamine CAS 179474-79-4

Unit Price: USD 1.0000 / Gram
Payment Type: T/T
Incoterm: CIF
Min. Order: 1 Gram
Delivery Time: 15 Days

Basic Info

Model No.: 179474-79-4

Additional Info

Packaging: As Quantity

Productivity: As Order


Transportation: Air

Place of Origin: CHINA

Supply Ability: IN STOCK

Product Description

1-(3-Methoxypropyl)-4-Piperidinamine cas number 179474-79-4 is an essential intermediates for Prucalopride, with the appearance of colorless to pale yellow transparent liquid, purity is more than 99%.How to get this prucalpride intermediate?Ttraditional methods of manufacture are obtained by methoxypropylation and amination of 4-piperidine copper salt monohydrate. Carbonyl conversion into amino is the key to synthesis, hydroxylamine hydrochloride can be used to form a carbonyl oxime, and then by the reduction of amino, this method requires two steps of reaction, operation is cumbersome. Now there is a new manufacturing method, reaction step is less, the reaction time is significantly shorter than the traditional manufacturing method with less side effects. Use 4-piperidone as the starting material, under alkaline conditions reaction with 1-bromo-3-methoxypropane,after the reaction completed, filtration, washing, drying,get the compound of 1- (3-methoxypropyl) Piperidine-4-one, and then dissolving the compound in formic acid by adding ammonium formate, refluxing, distilling off the solvent, adding saturated sodium carbonate to adjust the pH, extracting with ethyl acetate several times, drying the organic layer, and concentrating and distilling to obtain The final target compound.     

Thera. Category: Anti-Chronic Constipation

Cas No.: 179474-79-4 

Synonyms:1-(3-Methoxypropyl)-4-piperidinamine;4-AMino-1-(3-Methoxypropyl)piperidine;4-AMino-1-(3-Methoxypropy...;4-PiperidinaMine, 1-(3-Methoxypropyl)-;1-(3-Methoxypropyl)piperidin-4-aMine;Prucalopride Succinate interMediate B

MF:  C9H20N2O



Assay: ≥99%

Packing:Export worthy packing

Material Safety Data Sheet:Available on request

Usage:  Prucalopride Intermediate that is a selective, high affinity 5-HT4 receptor agonist for treatment of chronic constipation. 

Related Intermediates:

1) 4-Amino-5-Chloro-2,3-Dihydro-7-Benzofurancarboxylic Acid CAS 123654-26-2

2) Methyl 4-(Acetylamino)-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylate CAS 143878-29-9 

3) 1-(3-Methoxypropyl)-4-Piperidinamine( Prucalopride Intermediates) CAS 179474-79-4

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