|Unit Price:||USD 1.0000 / Kilogram |
|Min. Order:||1 Kilogram|
|Delivery Time:||15 Days|
Model No.: 491833-29-5
Packaging: AS REQUIRED
Place of Origin: CHINA
Supply Ability: TRUE MANUFACTURER
Eliglustat referred to as Genz 99067, CAS Number 491833-29-5, is a glucosyl-sphingosine synthase inhibitor, used as a specific I-type Geshe disease is the only first-line oral mediation. Goshen disease (GD) that is glucose mellitus disease, is a family of glycolipid metabolic diseases, chromosomal recessive inheritance, is the most common one in lysosomal deposition disease . Glucose mellitus is a soluble glycolipid material, is one of the components of the cell, widely found in the human body. Due to the lack of glucose cerebroside lipase caused glucose moss glycosides accumulate in the liver, spleen, bone and central nervous system mononuclear - macrophages and cause lesions. The listing of Eliglustat CAS 491833-29-5 has greatly changed the treatment of type I goshen disease.
The Preparation of Eliglustat is as following:1 - halogen 2 - nitroethane and pyrrolidine are reacting under the catalyst and the deacid reagent, Take the substitution reaction to produce 2- (pyrrolidin - 1 - yl) -1 - nitroethane, and then By its reaction with 2,3-dihydro-1,4-benzodioxan-6-aldehyde under the action of a chiral catalyst, then the product through nitro reduction and amidation reaction to get Eliglustat 491833-29-5. This kind of preparation method has been tested in many times, which is an ideal method.
Thera. Category: Inhibitors
Cas No.: 491833-29-5
Synonym:Eliglustat(Genz-99067);Eliglustat;Genz 99067;N-[(1R,2R)-2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(1-pyrrolidinylmethyl)ethyl]-octanamide;N-[(1R,2R)-1-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-(1- pyrrolidinyl)-2-propanyl]octanamide;
Molecular Weight: 404.54294
Packing: Export worthy packing
lMaterial Safety Data Sheet: Available on request
Usage: Synthesis Pharmaceutical Intermediates