Ethyl (R)-(+)-4-Chloro-3-Hydroxybutyrate CAS 90866-33-4

Payment Type: T/T
Incoterm: CIF
Min. Order: 1 Kilogram
Delivery Time: 15 Days

Basic Info

Model No.: 90866-33-4

Additional Info

Packaging: AS REQUIRED

Productivity: KGS


Transportation: Air

Place of Origin: CHINA


Certificate: ISO

Product Description

Ethyl (R)-(+)-4-chloro-3-hydroxybutyrate CAS number 90866-33-4, which is an important chiral building block for the synthesis of (R)-γ-amino-β- Butyric acid, L-carnitine and (-)-large lactam can also be converted to a synthon of (+)-neomycin and chiral 2,5-cyclohexadienone. The method for preparing optically chiral Ethyl (R)-(+)-4-chloro-3-hydroxybutyrate can be classified into a chemical catalytic hydrogenation method and a biocatalytic method. Among them, the chemical catalytic hydrogenation method uses 4-chloroacetoacetate as a reaction precursor and a rare metal ruthenium complex as a catalyst for asymmetric catalytic hydrogenation. The advantage of this method is that it is suitable for large-scale production, but This method has the disadvantages of high catalyst cost, unfriendly environment and unsatisfactory optical purity of the product, and requires high pressure in the catalytic process, so the equipment requirements are also high. The biocatalytic method has the advantages of high activity, high stereoselectivity, mild reaction conditions and good social benefits. Therefore, the preparation of Ethyl (R)-(+)-4-chloro-3-hydroxybutyrate CAS number 90866-33-4 by biocatalyst is highly favored by researchers.
Biocatalytic asymmetric reduction of Ethyl (R)-(+)-4-chloro-3-hydroxybutyrate CAS number 90866-33-4 is mainly carried out under the catalytic action of dehydrogenase or carbonyl reductase, and also requires the reduction of coenzyme NADH or NADPH. participate. However, the coenzyme NADH or NADPH is expensive and therefore limits its application. Coenzyme NADH or NADPH regeneration and circulation can be economically achieved using a coenzyme circulation system throughout the cell (Wang L. J., et al. Bioresour. Technol. 2011, 102, 7023-7028). The chiral purity of the final product catalyzed by carbonyl reductase reported in some literature is only about 99%, mainly due to the lower concentration of its catalytic substrate 4-chloroacetoacetate and usually needs to be divided during the reaction. Batch feed, or add expensive NADH or NADPH to achieve a satisfactory substrate concentration. And most of the literature reports about the biosynthesis of (S)-4-chloro-3-hydroxybutyrate. Therefore, it is imperative to find a highly active and selective strain to reduce ethyl 4-chloroacetoacetate to synthesizeEthyl (R)-(+)-4-chloro-3-hydroxybutyrate CAS 90866-33-4.
A research team constructed a recombinant reductase strain, Escherichia coli, using genome engineering. High-efficiency synthesis of (R)-(+)-4-chloro-3-hydroxybutyric acid ethyl ester can be achieved by using its whole-cell catalyst with glucose as a secondary substrate and low-cost NAD+ to achieve coenzyme regeneration. No batch feeding is required during the reaction, and in the 2 L reaction system, the substrate concentration can reach 800-6000 mM, The rate of Ethyl (R)-(+)-4-chloro-3-hydroxybutyrate CAS number 90866-33-4 can be as high as 99.0%. Therefore, it has potential application prospects.

Thera. Category: Organic intermediate

Cas No.:90866-33-4



Molecular Formula:C6H11ClO3

Molecular Weight:166.6 


PackingExport worthy packing

lMaterial Safety Data SheetAvailable on request 

Active Pharmaceutical Ingredients> Cas 90098-04-7,Rebamipide Named In Mucosta With GMP Standard
Active Pharmaceutical Ingredients> Functional Dyspepsia Treatment Acotiamide Hydrochloride Trihydrate CAS 773092-05-0
Active Pharmaceutical Ingredients> Acotiamide Hydrochloride For Gastric Motility Improvement CAS 185104-11-4
Contract Manufacturing> ASCORBYL GLUCOSIDE Used for Comesitc Additive CAS 129499-78-1
Pharmaceutical Intermediates> Anti-Ulcerative> 2-Aminothiazole-4-ethylformate For Making Acotiamide Cas 5398-36-7
Pharmaceutical Intermediates> Anti-Ulcerative> Acotiamide INT CAS NUMBER 185105-98-0
Pharmaceutical Intermediates> Anti-Cardiovascular> Azilsartan Used for Hypertension Treatment CAS 147403-03-0
Pharmaceutical Intermediates> Anti-Diabetes> Sitagliptin Phosphate Monohydrate Treated for Type 2 diabetes CAS Number 654671-77-9
Pharmaceutical Intermediates> Anti-Ulcerative> Cas 132210-24-3, 2-Amino-3-(1,2-dihydro-2-oxo-quinoline-4-yl)Propanoic acid Hydrochloride For Rebamipide
Pharmaceutical Intermediates> Anti-Ulcerative> Cas 1068-90-2 White Crystalline Powder Diethyl Acetamidomalonate For Rebamipide(DAAM)
Active Pharmaceutical Ingredients> 6027-23-2, Hordenine HCL Powder
Pharmaceutical Intermediates> Anti-Ulcerative> Cas 4876-10-2,4-Bromomethyl-2(1H)-quinolinone (BMQ) For Rebamipide/ Mucosta
Pharmaceutical Intermediates> Anti-Respiratory> CAS 2338-18-3, 2-Aminoindan hydrochloride For Making Indacaterol
Pharmaceutical Intermediates> Anti-Respiratory> CAS 312753-53-0/ 5,6-Diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride Used for Indacaterol
Pharmaceutical Intermediates> Anti-Respiratory> 312753-53-0, Indacaterol Intermediate
Pharmaceutical Intermediates> Anti-Respiratory> 100331-89-3, Indacaterol Intermediate

© 2019 CHINA WAY. All Rights Reserved.  Taizhou Volsen Chemical Co., Ltd.,  Inc.   All rights reserved. site map.  sitemap.html