High Quality Isoxepac 55453-87-7 For OLOPATADINE HCL

Payment Type: L/C,T/T
Incoterm: FOB
Min. Order: 1 Kilogram
Delivery Time: 15 Days

Basic Info

Model No.: 55453-87-7

Additional Info

Packaging: AS REQUIRED

Productivity: KGS


Transportation: Air

Place of Origin: CHINA

Supply Ability: 100KG

Certificate: ISO

Product Description

Isoxepac CAS number 55453-87-7,which is the important intermediate synthesis of a new preferred antiallergic drug Olopatadine hydrochloride , but because of the current domestic companies use of condensation, hydrolysis, acidification, cyclization four-step reaction and multiple extraction and recrystallization traditional process route of operation, the cumbersome traditional process determines the cost of the domestic Isoxepac, and the second step of the traditional process is a reversible reaction, resulting in that there are always 8% un-hydrolyzed ester structure impurities into the product , And then form of Isoxepac methyl ester impurity,the characteristic of Isoxepac methyl ester is very similar to product. It brought great trouble in the post-refining and other post-processing,it needs to use ethyl acetate, glacial acetic acid, water and the toxicity of acetonitrile,recrystallize for 4 to 5 times, low purity, poor color (yellow to light yellow), high impurity content led to the domestic application of Isoxepac many shortcomings in the application of long-,depend on a large number of Imported price is expensive.
In Japan, the quality of Isoxepac is the highest in the world, but there are high production costs and a large amount of wastes containing phosphorus in industry. Japan's kyowahakko bio use the following synthesis route: o-methyl ethyl benzoate and ethyl p-hydroxyphenylacetate under the effect of potassium carbonate and potassium hydroxide,take condensation reaction, and then use phosphorus pentoxide as dehydration agent,take Cyclization Reaction to obtain Isoxepac CAS number 55453-87-7, this process exist some flaws, mainly reflected in the higher cost, leading to the import price of Isoxepac around 3000RMB, and the use phosphorus pentoxide as a dehydrating agent has great rish and damage to the environment, will produce a large number of phosphorus-containing industrial waste, does not meet the new area of energy-saving emission reduction and green, safe production requirements.

Thera. Category:allergic conjunctivitis

Cas No.:55453-87-7

Synonym:artil;e)oxepin-2-aceticacid,6,11-dihydro-11-oxo-dibenz(;hp549;DIBENZ[B,E]OXEPIN-2-ACETIC ACID, 6,11-DIOHYDRO-11-OXO;isoxepac;6,11-DIHYDRO-11-OXO-DIBENZ[B,E]OXEPIN-2-ACETIC ACID;(11-OXO-6,11-DIHYDRODIBENZO[B,E]OXEPIN-2-YL)ACETIC ACID;ND4-B2;


Molecular Weight:268.26

Molecular formula:C16H12O4

Purity: ≥99.%

Appearance: White Crystalline solid

Packing:Export worthy packing

Material Safety Data Sheet:Available on request

Usage:It can treat eye itching caused by pink eye

Related intermediate:

Chemical name Specification Color
Isoxepac HPLC 99.0%  offer white powder
Melt point 137~142
Loss on drying 0.5%



HPLC 99.0% white crystalline powder
Single impurity 0.5%
Loss on drying 0.5% 
Assay 98.5%
OLOPATADINE HCL HPLC 99.75%  white crystalline powder
Single impurity 0.1%
PH 2.0~4.0
Loss on drying 0.3% 
Residue on ignition

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